Desoxyrhapontigenin
Catalog No: CFN90854
Desoxyrhapontigenin has significant hypoglycemic, anti-inflammatory, and antioxidant effects, it shows inhibition of iNOS and COX-2 expression via the down-regulation of the MAPK signaling pathways and the inhibition of NF-κB and Akt activation.
Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1(HO-1) expression in macrophages and inflammatory lung injury, and HO-1 is an important anti-inflammatory, antioxidative and cytoprotective enzyme. Desoxyrhapontigenin shows significant monoamine oxidase inhibitory activities with the IC50 value of 11.5 ± 1.1 uM.
Diammonium glycyrrhizinate
Catalog No: CFN96843
Diammonium glycyrrhizinate shows antiviral, and anti-inflammatory effects, it can reduce inflammatory injury in a rat model of ulcerative colitis, this may occur via suppression of NF-kappaB, TNF-alpha and ICAM-1 in colonic mucosa. Diammonium glycyrrhizinate may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way.
Diammonium glycyrrhizinate exerts potential beneficial effects on Alzheimer's disease, it can attenuate Aβ(1-42)-induced neuronal injury by preventing mitochondrial dysfunction and oxidative stress and improve cognitive impairment in Aβ(1-42)-induced AD mice.
Diammonium glycyrrhizinate also can inhibit airway smooth muscle proliferation possibly through up- regulation of PPARγ in a murine model of chronic asthma.