p-Hydroxy-cinnamic acid

p-Hydroxy-cinnamic acid
Product Name p-Hydroxy-cinnamic acid
CAS No.: 7400-08-0
Catalog No.: CFN98179
Molecular Formula: C9H8O3
Molecular Weight: 164.16 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Powder
Targets: NF-kB | Antifection
Source: The barks of Cinnamomum cassia Presl
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $70/20mg
p-Hydroxy-cinnamic acid may have in vitro antimalarial activity. p-Hydroxycinnamic acid and β-cryptoxanthin have anti-osteoporotic properties in vivo, they can antagonize NF-κB activation in MC3T3 preosteoblastic cells。
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain.[Pubmed: 21814840]
    For decades, drug resistance has been the major obstacle in the fight against malaria, and the search for new drugs together with the combination therapy constitutes the major approach in responding to this situation.
    METHODS AND RESULTS:
    The present study aims at assessing the in vitro antimalarial activity of four compounds isolated from Kigelia africana stem bark (atranorin - KAE1, specicoside - KAE7, 2β,3β,19α-trihydroxy-urs-12-20-en-28-oic acid - KAE3, and p-Hydroxy-cinnamic acid - KAE10) and their drug interactions among themselves and their combination effects with quinine and artemether. The antiplasmodial activity and drug interactions were evaluated against the multidrug-resistant W2mef strain of Plasmodium falciparum using the parasite lactate dehydrogenase assay. Three of the four compounds tested were significantly active against W2mef: specicoside (IC(50) = 1.02 ± 0.17 μM), 2β,3β,19α-trihydroxy-urs-12-en-28-oic acid (IC(50) = 1.86 ± 0.15 μM) and atranorin (IC(50) = 1.78 ± 0.18 μM), whereas p-Hydroxy-cinnamic acid showed a weak activity (IC(50) = 12.89 ± 0.87 μM). A slight synergistic effect was observed between atranorin and 2β,3β,19α-trihydroxy-urs-12-en-28-oic acid (Combination index, CI = 0.82) whereas the interaction between specicoside and p-Hydroxy-cinnamic acid were instead antagonistic (CI = 2.67).
    CONCLUSIONS:
    All the three compounds showed synergistic effects with artemether, unlike the slight antagonistic interactions of atranorin and 2β,3β,19α-trihydroxy-urs-12-en-28-oic acid in combination with quinine. K. africana compounds are therefore likely to serve as leads in the development of new partner drugs in artemether-based combination therapy.
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    The bone anabolic carotenoids p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblasts.[Pubmed: 21475879]
    The carotene p-hydroxycinnamic acid and the xanthophyll β-cryptoxanthin are members of the carotenoid family of plant-derived pigments, which are endowed with anti-osteoporotic properties in vivo. p-Hydroxycinnamic acid and β-cryptoxanthin have been demonstrated to stimulate osteoblastic bone formation while simultaneously repressing osteoclastic bone resorption in vitro. However, their mechanisms of action remain poorly elucidated. It is well established that the NF-;kgr;B signal transduction pathway plays a critical role in osteoclast differentiation. Moreover, we recently demonstrated that NF-κB activity potently antagonizes osteoblastic differentiation and mineralization in vitro.
    METHODS AND RESULTS:
    In this study, we used transient transfection assays of a NF-κB luciferase reporter to demonstrate that p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblastic cells.
    CONCLUSIONS:
    The data obtained suggest that NF-κB may be a common molecular target by which several bone active agents, including carotenoids, promote osteoblastic bone formation.
    Yao Xue Xue Bao. 2014 Aug;49(8):1150-4.
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    CONCLUSIONS:
    Compound 2-5 are isolated from the lateral roots of Aconitum carmichaelii Debx. for the first time.
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