Triptonide
Triptonide is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities, it possesses anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Zhongguo Yao Li Xue Bao. 1993 May;14(3):238-42.
Effects of triptonide on mouse immune functions.[Pubmed:
8237400]
METHODS AND RESULTS:
Triptonide (Tri) extracted from Tripterygium wilfordii Hook inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 microgram.ml-1. It showed a suppressive effect on one way mixed lymphocyte culture (MLC) at 0.1-0.4 microgram.ml-1. The lymphocytes harvested from the first Tri (0.4 microgram.ml-1)-containing MLC inhibited the second MLC after being washed and irradiated with 60Co source (30 Gy). Serum anti-sheep red blood cell antibody (hemolysin) formation and clearance of charcoal particles were also suppressed by Tri in vivo. Although delayed hypersensitivity (DH) reaction to dinitrofluorobenzene (DNFB) was inhibited by Tri 1.2, 2.5, and 5.0 mg.kg-1 (ip, qd x 5 d), the spleen cell interleukin-2 secretion activities of these mice were not suppressed. Graft vs host reaction (GVHR) was not inhibited by Tri 2.5 and 5.0 mg.kg-1 (ig, qd x 5 d). Helper T cells (Th)/suppressor T cells (Ts) ratio was reduced at 2.5 mg.kg-1. The effects of Tri on mouse thymus and spleen weight were related to the age. Tri (1.2, 2.5, 5.0 mg.kg-1) had no effect on thymus and spleen weights in 8-wk-old mice. However, it increased the thymus and spleen weights in 12-wk-old mice at doses of 1.2 and 2.5 mg.kg-1.
CONCLUSIONS:
The data indicated that Tri had extensive suppressive effects on mouse immune function and its mechanism may be related to the reduction of Th/Ts ratio and the induction of Ts cells.
Cell Mol Immunol. 2014 Oct 13.
Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells.[Pubmed:
25308753]
IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37.
METHODS AND RESULTS:
In this work, we uncovered, for the first time, that two main bioactive components, triptolide and Triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors.
CONCLUSIONS:
Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and Triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways.C
Sci Rep. 2016 Sep 6;6:32779.
Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin.[Pubmed:
27596363]
Abnormal activation of canonical Wnt/β-catenin signaling is implicated in many diseases including cancer. As a result, therapeutic agents that disrupt this signaling pathway have been highly sought after. Triptonide is a key bioactive small molecule identified in a traditional Chinese medicine named Tripterygium wilfordii Hook F., and it has a broad spectrum of biological functions. Here we show that Triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. In addition, Triptonide treatment robustly rescued the zebrafish "eyeless" phenotype induced by GSK-3β antagonist 6-bromoindirubin-30-oxime (BIO) for Wnt signaling activation during embryonic gastrulation. Finally, Triptonide effectively induced apoptosis of Wnt-dependent cancer cells, supporting the therapeutic potential of Triptonide.
Chinese Journal of Hospital Pharmacy, 2006, 26(6):695-7.
Effect of triptonide on inflammation and immunity function.[Reference:
WebLink]
METHODS AND RESULTS:
To study the effect of Triptonide on inflammation and immunity function.METHODS The effect of Triptonide on acute auricle inflammation,capillary permeability,the index of immune organ,the clearance of charcoal particles,the level of spleen cell antibody,the level of serum hemolysin and T-lymphocytes percentage were observed in mice by ig.RESULTS Triptonide could apparently inhibit auricle inflammation and capillary permeability,decrease the index of thymus and the clearance rate of charcoal particles and suppress the formation of spleen cell antibody,reduce the content of serum hemolysin and T-lymphocytes percentage in mice.
CONCLUSIONS:
Triptonide has good anti-inflammatory and immunosuppressive action.
