Tripdiolide
Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Arthritis Rheum. 2008 Jun;58(6):1774-83.
Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.[Pubmed:
18512813 ]
Triptolide and Tripdiolide are thought to be active components of the Chinese antirheumatic herbal remedy Tripterygium wilfordii Hook F, which has been shown to be effective in treating murine lupus nephritis. This study was undertaken to examine the therapeutic effect of triptolide and Tripdiolide on established lupus nephritis in (NZB x NZW)F1 mice.The mean level of anti-dsDNA antibody in mice treated with Tripdiolide was lower than that in the vehicle-treated mice upon completion of the treatment course. Production of tumor necrosis factor, interleukin-6, and monocyte chemoattractant protein 1 by spleen cells was also decreased after diterpenoid therapy.Therapy with triptolide or Tripdiolide significantly ameliorated lupus nephritis in (NZB x NZW)F1 mice, reduced cytokine and chemokine production, and prolonged survival.
Phytochem Anal. 2008 Jul-Aug;19(4):348-52.
Determination of tripdiolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reversed-phase high-performance liquid chromatography.[Pubmed:
18288676]
Extracts of Tripterygium wilfordii Hook F. have been widely used in China to treat a variety of autoimmune and inflammatory diseases. The diterpenoids triptolide and Tripdiolide are two major active components in the T. wilfordii ethyl acetate extract. An efficient solid-phase extraction and high-performance liquid chromatography (SPE-HPLC) method to measure triptolide content in the extract has been previously reported. However, a suitable means of Tripdiolide quantification is not available because of interfering compounds in the extract that co-elute with Tripdiolide. Therefore, this paper describes a method wherein Tripdiolide content can be measured from a small amount of the extract.
METHODS AND RESULTS:
The extract solution (600 microL) was applied into an aminopropyl SPE tube. Triptolide was eluted with dichloromethane:methanol (1 mL, 49:1 v/v), followed by Tripdiolide elution with dichloromethane:methanol (3 mL, 17:3 v/v). The Tripdiolide eluate was analysed by HPLC using an isocratic solvent system and was quantified by measuring the peak area at 219 nm. The contents of triptolide and Tripdiolide in the extract were determined to be 807.32 +/- 51.94 and 366.13 +/- 17.21 microg/g of extract, respectively. Since Tripdiolide is biologically active and makes up a considerable portion of the extract, for extract quality control and standardisation purposes, it should be measured along with triptolide using the proposed SPE-HPLC method.
Phytochemistry. 2007 Apr;68(8):1172-8.
Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.[Pubmed:
17399748]
The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives.
METHODS AND RESULTS:
A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from Tripdiolide.
Can. J.Chem., 1981, 59(17):2677-83.
Cytotoxic diterpenes triptolide, tripdiolide, and cytotoxic triterpenes from tissue cultures of Tripterygium wilfordii[Reference:
WebLink]
METHODS AND RESULTS:
Plant tissue cultures of Tripterygium wilfordii Hook F produced the cytotoxic diterpene triepoxides Tripdiolide (1) and triptolide (2) in yields that were 16 and 3 times greater, respectively, than those observed in the plant itself. Other diterpenes, dehydroabietic acid (3) and 15-hydroxy-18-norabieta-3,8,11,13-tetraene-3-oic acid methyl ester (4) were also isolated. Co-occuring in these cultures were the cytotoxic quinone-methides, celastrol (5), compound 6, and compound 7. Other triterpenes produced were oleanolic acid (8) and polpunonic acid (9). β-Sitosterol (17) was also isolated. The proposed structure of 4 was confirmed by synthesis starting from compound 3.
CONCLUSIONS:
Cytotoxic data are reported, and a possible biosynthetic relationship among dehydroabietic acid, compound 4, and Tripdiolide (1) is presented.
