Trimethylgallic acid
Trimethylgallic acid esters are potent antioxidants and inhibitor of cytokine production, can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress; they also exert hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pharmacological Reports Pr, 2014, 66(4): 606-12.
Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.[Pubmed:
24948061 ]
METHODS AND RESULTS:
Chronic treatment with Trimethylgallic acid esters for 15 days significantly reversed the chronic stress-induced behavioral (impaired locomotor activity, anxiety-like behavior, and decreased percentage of memory retention), biochemical (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities), and inflammation surge (serum TNF-α) in stressed mice.
CONCLUSIONS:
The study revealed that Trimethylgallic acid esters could ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress.
Indian J. Exp. Biol., 2015, 53(12):803-9.
Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.[Pubmed:
26742325]
Gallic acid and its derivatives are potential therapeutic agents for treating various oxidative stress mediated disorders.
METHODS AND RESULTS:
In the present study, we investigated the hepatoprotective effects of newly synthesized conjugated Trimethylgallic acid (TMGA) esters against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Animals were pre-treated with TMGA esters at their respective doses for 7 days against CCl4-induced hepatotoxicity. The histopathological changes were evaluated to find out degenerative fatty changes including vacuole formation, inflammation and tissue necrosis. Various biomarkers of oxidative stress (lipid peroxidation, glutathione levels, and endogenous antioxidant enzyme activities), liver enzymes (AST and ALT), triacylglycerol and cholesterol were evaluated.
