Trimethylgallic acid

Pharmacological Reports Pr, 2014, 66(4): 606-12.

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.[Pubmed: 24948061 ]

METHODS AND RESULTS:
Chronic treatment with Trimethylgallic acid esters for 15 days significantly reversed the chronic stress-induced behavioral (impaired locomotor activity, anxiety-like behavior, and decreased percentage of memory retention), biochemical (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities), and inflammation surge (serum TNF-α) in stressed mice.
CONCLUSIONS:
The study revealed that Trimethylgallic acid esters could ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress.

Indian J. Exp. Biol., 2015, 53(12):803-9.

Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.[Pubmed: 26742325]

Gallic acid and its derivatives are potential therapeutic agents for treating various oxidative stress mediated disorders.
METHODS AND RESULTS:
In the present study, we investigated the hepatoprotective effects of newly synthesized conjugated Trimethylgallic acid (TMGA) esters against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Animals were pre-treated with TMGA esters at their respective doses for 7 days against CCl4-induced hepatotoxicity. The histopathological changes were evaluated to find out degenerative fatty changes including vacuole formation, inflammation and tissue necrosis. Various biomarkers of oxidative stress (lipid peroxidation, glutathione levels, and endogenous antioxidant enzyme activities), liver enzymes (AST and ALT), triacylglycerol and cholesterol were evaluated.