Tribuloside
Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, it can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect.
Tribuloside exhibits antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Analytical Methods2018, 10(27)
Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
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Nat Prod Res. 2014;28(6):351-8.
A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts.[Pubmed:
24443810]
A new cinnamolyglycoflavonoid 3-cinnamoylTribuloside (1), its precursor Tribuloside and two known flavonoid glycosides afzelin and astilbin were isolated from Heritiera littoralis Dryand (Sterculiaceae) ethanolic leaf extract.
METHODS AND RESULTS:
The dichloromethane leaf extract afforded two known pentacyclic triterpenoids, 3β-taraxerol and friedelin. Extracts and compounds isolated therefrom, with the exception of 3β-taraxerol, exhibited antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL for the crude extracts and MICs in the range of 1.6-0.8 mg/mL for the pure compounds. The extracts together with 3-cinnamoylTribuloside (1), Tribuloside and astilbin exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.
CONCLUSIONS:
The compounds that showed dual activities could be further evaluated under clinical settings for co-administration with standard anti-tuberculosis drugs.
Acta Chinese Medicine & Pharmacology,2008,36(3) :13-16.
Effect of tribuloside on geurogenesis in dentate gyrus of chronic stress depression rats.[Reference:
WebLink]
To observe the effect of Tribuloside on behavior and geurogenesis in dentate gyrus of chronic stress depression rats.
METHODS AND RESULTS:
All rats except the control group were singly housed and exposed an unpredicted sequence of mild stressor.The behavior of rats was detected by open-field test.And geurogenesis in dentate gyrus was observed by the Bromodeoxyuridine labelling method. Compared with control group,the weight of rats in model group showed significantly decreased(41.00±11.43g).Squares crossed(17.00±9.04),rears(6.90±4.75),and grooming(4.56±1.71s)in open-field test reduced,while time of staying in central square(4.38±0.92s)and defecation(9.34±3.01)were increased.And fluoxetine or Tribuloside significantly improve behavioral disorder and BrdU immunoreactive cells(no.1 Tribuloside group 10.23±3.81;no.2Tribuloside group 10.92±2.16;fluoxetine group 11.46±2.94).
CONCLUSIONS:
Tribuloside can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect.
