Trachelogenin

Trachelogenin
Product Name Trachelogenin
CAS No.: 34209-69-3
Catalog No.: CFN90598
Molecular Formula: C21H24O7
Molecular Weight: 388.15 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Targets: Wnt/β-catenin | GSK-3 | c-Myc
Source: The herbs of Trachelospermum jasminoides (Lindl.) Lem.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Trachelogenin has antiproliferative effect, the mechanism is related to affect the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Clin Med.2019, 8(10):E1664
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Biomimetics (Basel).2022, 7(4):154.
  • J Nat Med.2018, 72(3):734-744
  • Plos One.2019, 15(2):e0220084
  • Food Funct.2022, 13(23):12105-12120.
  • Microb Pathog.2019, 131:128-134
  • BMC Cancer. 2021, 21(1):91.
  • Molecules.2020 ,25(16):3697.
  • Phytother Res.2022, 35844057.
  • Lappaol F

    Catalog No: CFN95069
    CAS No: 69394-17-8
    Price: $368/10mg
    (+)-Matairesinol

    Catalog No: CFN96715
    CAS No: 148409-36-3
    Price: Inquiry(manager@chemfaces.com)
    Isosalicifolin

    Catalog No: CFN96234
    CAS No: 156974-99-1
    Price: Inquiry(manager@chemfaces.com)
    Nortrachelogenin

    Catalog No: CFN98454
    CAS No: 34444-37-6
    Price: $338/10mg
    (+)-Nortrachelogenin

    Catalog No: CFN96714
    CAS No: 61521-74-2
    Price: Inquiry(manager@chemfaces.com)
    (7R)-Methoxy-8-epi-matairesinol

    Catalog No: CFN89300
    CAS No: 198827-23-5
    Price: Inquiry(manager@chemfaces.com)
    Trachelogenin

    Catalog No: CFN90598
    CAS No: 34209-69-3
    Price: $318/10mg
    Nortracheloside

    Catalog No: CFN93080
    CAS No: 33464-78-7
    Price: $318/5mg
    Tracheloside

    Catalog No: CFN90597
    CAS No: 33464-71-0
    Price: $50/20mg
    Trachelogenin 4'-O-beta-gentiobioside

    Catalog No: CFN95235
    CAS No: 106647-13-6
    Price: $218/10mg
    Fitoterapia. 2015 Jan;100:19-26.
    Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line.[Pubmed: 25447161]
    The molecular constituents of Cirsium brachycephalum fruits were identified, quantified and isolated for the first time.
    METHODS AND RESULTS:
    The lignan glycoside tracheloside was the main compound, which was transformed quantitatively into its aglycone Trachelogenin by endogenous enzymatic treatment of the fruit. Following this transformation by high performance liquid chromatography (HPLC) hyphenated with UV and mass spectrometry (MS) detections on a quantitative basis, the enzyme-hydrolyzed fruit was found to be the richest raw material containing Trachelogenin (17.2mg/g) reported to date. Thus, the enzyme-hydrolyzed fruit was used to isolate Trachelogenin using preparative HPLC in order to (1) unambiguously confirm its identity by gas chromatography-MS, nuclear magnetic resonance spectroscopy and optical rotation, and (2) investigate its in vitro antiproliferative activities against the SW480 colon adenocarcinoma cell line.
    CONCLUSIONS:
    Trachelogenin significantly affected the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner. These changes account for the antiproliferative effects of Trachelogenin.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1033-7.
    Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography/tandem mass spectrometry.[Pubmed: 21482203]
    We developed and validated a quantitative method for simultaneously determining the concentrations of tracheloside and Trachelogenin in rat plasma.
    METHODS AND RESULTS:
    Plasma samples were prepared by liquid-liquid extraction with ethyl acetate. Isocratic chromatographic separation was performed on a reversed-phase Diamonsil C(18) column (4.6×200 mm, 5 μm). The mobile phase consisted of methanol and 10mM aqueous ammonium formate (80:20, v/v). Analyte detection was achieved by positive electrospray ionization (ESI) tandem mass spectrometry. Calibration was performed by internal standardization with glipizide, and regression curves ranging from 0.625 to 625 ng/mL were constructed for both the analytes. The intra- and inter-day precision values were below 8%, and accuracy ranged from -5.33% to 2.53% in all quality control samples.
    CONCLUSIONS:
    In this study, the validated method was successfully applied to determine the pharmacokinetic profile of tracheloside and Trachelogenin in rat plasma after oral and intravenous administration of trachelospermi total lignans.
    Naringin 4'-glucoside

    Catalog No: CFN95014
    CAS No: 17257-21-5
    Price: $338/5mg
    3-O-[5'''-O-feruloyl-beta-D-apiofuranosyl(1'''->2'')-beta-D-glucopyranosyl] rhamnocitrin

    Catalog No: CFN95154
    CAS No: 148210-00-8
    Price: $413/5mg
    (3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol

    Catalog No: CFN95227
    CAS No: 232261-31-3
    Price: $318/5mg
    Nortrachelogenin-8'-O-beta-glucoside

    Catalog No: CFN95234
    CAS No: 858127-38-5
    Price: $368/10mg
    N1,N5,N10-(E)-tri-p-coumaroylspermidine

    Catalog No: CFN95256
    CAS No: 364368-18-3
    Price: $388/10mg
    Phyllanthusiin C

    Catalog No: CFN95260
    CAS No: 142674-52-0
    Price: $318/5mg
    Sibiricose A4

    Catalog No: CFN95298
    CAS No: 241125-73-5
    Price: $318/5mg
    Batatasin V

    Catalog No: CFN95320
    CAS No: 65817-45-0
    Price: $318/5mg
    Mahuannin J

    Catalog No: CFN95533
    CAS No: N/A
    Price: $318/5mg
    Schisphenlignan I

    Catalog No: CFN95586
    CAS No: 1542234-14-9
    Price: $318/5mg