Traxillaside
Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Applied Biological Chemistry2024, 67:66.
Sci Rep.2019, 9(1):4646
Front. Pharmacol.2022, 901563.
Am J Chin Med.2022, 1-20.
J Food Biochem.2019, 43(9):e12970
Int J Mol Sci.2022, 23(11):6104.
Mol Med Rep.2015, 12(5):7789-95
J Appl Biol Chem.2024, 67:39,281-288.
Dent Mater J. 2024, dmj.2023-294.
Nat Prod Sci.2018, 24(2):109-114
Related and Featured Products
Planta Med. 2001 Jul;67(5):470-2.
Neuroprotective dibenzylbutyrolactone lignans of Torreya nucifera.[Pubmed:
11488466 ]
METHODS AND RESULTS:
The methanolic extract of the bark of Torreya nucifera Sieb. et Zucc. (Taxaceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. (-)-Arctigenin (1), (-)-traxillagenin (2), arctiin (4), Traxillaside (5), and a newly-reported compound 3 (-)-4'-demethyltraxillagenin [(2R,3R)-2-(4''-hydroxy-3''-methoxybenzyl)-3-(4'-hydroxy-3',5'-dimethoxybenzyl)-butyrolactone] were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques.
CONCLUSIONS:
These lignans and their glycosides had significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells at concentrations ranging from 0.01 microM to 10.0 microM.
Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1581-5.
Trace chemical constituents contained in Trachelospermum jasminoides and structure identification.[Pubmed:
22993985]
To study trace chemical constituents contained in traditional Chinese medicine Trachelospermum jasminoides.
METHODS AND RESULTS:
The chemical constituents were separated and purified by using such column chromatographic methods as ployamide, silica gel, Sephadex LH-20 and ODS, and their structures were identified on the basis of spectral data analysis.
Eleven compounds were separated from T. jasminoides and identified as bergenin (1), chrysoeriol-7-O-beta-D-glucoside (2), arctigenin-4'-O-beta-gentiobioside (3), matairesinol 4'-O-beta-gentiobioside (4), traxillagenin (5), Traxillaside (6), 4-demethyltraxillagenin (7), luteolin-7-O-beta-gentiobioside (8), arctiin (9), trachelogenin-4'-O-beta-gentiobioside (10) and luteolin-7-O-beta-D-glucoside (11).
CONCLUSIONS:
Compounds 1 and 2 were separated from Trachelospermum genus for the first time, while compounds 3-7 were separated from this plant for the first time.
