Scabertopin
Scabertopin exhibits significant antitumor effect in vitro in a concentration-dependent manner.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Exp Oncol. 2006 Jun;28(2):106-9.
Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L.[Pubmed:
16837899]
To evaluate antitumor activity of sesquiterpene lactones (Scabertopin (ES-2), isoScabertopin (ES-3), deoxyelephantopin (ES-4), isodeoxyelephantopin (ES-5)) isolated from Elephantopus scaber L. in vitro and in vivo.
METHODS AND RESULTS:
SMMC-7721, Caco-2 and HeLa cell lines were treated with ES-2,3,4,5. Cell viability was determined by MTT assay. Agarose gel electrophoresis was used to detect DNA fragmentation. To evaluate in vivo antitumor activity of ES-4, experimental murine tumor model was used.
CONCLUSIONS:
It was shown that Scabertopin, ES-4, ES-5 exhibited significant antitumor effect in vitro in a concentration-dependent manner.
