Salvianolic acid F

Salvianolic acid F
Product Name Salvianolic acid F
CAS No.: 158732-59-3
Catalog No.: CFN90811
Molecular Formula: C17H14O6
Molecular Weight: 314.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: Caspase
Source: The roots of Salvia miltiorrhiza Bge.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $596/10mg
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • BMC Complement Altern Med.2017 Aug 9;
  • Biofactors.2017 Oct 24.
  • Analytical sci. & Tech2016
  • Evid Based Complement Alternat Med. 2017:6360836.
  • Food Res Int. 2017 Jun;
  • Chem Biol Interact. 2016 Dec 25
  • Journal of Pharmaceutical Analysis2016 May 5;
  • Sci Rep. 2017 Jan 9;
  • Biochem Biophys Res Commun.2017 Jan 22;
  • Kor. J. Pharmacogn.47(1):62-72(2016)
  • Gnetucleistol D

    Catalog No: CFN92443
    CAS No: 629643-26-1
    Price: Inquiry(manager@chemfaces.com)
    Gnetol

    Catalog No: CFN92425
    CAS No: 86361-55-9
    Price: $218/5mg
    Gnetucleistol B

    Catalog No: CFN92678
    CAS No: 864763-60-0
    Price: Inquiry(manager@chemfaces.com)
    Salvianolic acid F

    Catalog No: CFN90811
    CAS No: 158732-59-3
    Price: $596/10mg
    Isorhapotogenin

    Catalog No: CFN92426
    CAS No: 32507-66-7
    Price: $218/20mg
    Tristin

    Catalog No: CFN97824
    CAS No: 139101-67-0
    Price: Inquiry(manager@chemfaces.com)
    Rhapontigenin

    Catalog No: CFN92607
    CAS No: 500-65-2
    Price: $178/20mg
    Rhaponiticin

    Catalog No: CFN98569
    CAS No: 155-58-8
    Price: $60/20mg
    Rhapontigenin 3'-O-glucoside

    Catalog No: CFN90749
    CAS No: 94356-22-6
    Price: $358/10mg
    Piceatannol 3'-O-glucoside

    Catalog No: CFN90750
    CAS No: 94356-26-0
    Price: $308/10mg
    Eur. J. Org. Chem., 2016, 36:5941–9.
    Divergent Synthesis of Styryl–Cinnamate Hybrid Analogues Inspired by the Natural Product Salvianolic Acid F as a Premise To Investigate Their Anticancer Activity and Its Metabolomic Profiling[Reference: WebLink]
    The natural product Salvianolic acid F- inspired protecting-group-free synthesis of hydroxylated styryl-cinnamate hybrids (C6-C2-C6-C3 unit) has been achieved by step-economical route via sequential double C-C bond formation in one pot.
    METHODS AND RESULTS:
    The present method involves multiple reactions (Perkin-condensation/ decarboxylation-Heck cross-coupling reactions) using simple precursors (i.e. hydroxylated benzaldehyde, arylacetic acid and acrylic acid derivatives) in one pot which yields desired unnatural small hybrid molecules (1-12) in varying yields of 35-65%with E-selectivity under microwave irradiation whereas the reported conventional route for synthesis of Salvianolic acid F itself requires six steps with an overall yield of 10.0% besides tedious separation of E/Z isomers that arise from Wittig reaction.Apart from an economical synthesis and products diversity, we herein report the potential of some hybrid molecules (3,8,10 and 11), with the catecholic core, to selectively inhibit glioma cells. The intrinsic mode of action (MOA) for our lead molecule involving caspase 6 and quinonemethide pathway is also reported based on 1HNMR-guided metabolomic profiling.
    CONCLUSIONS:
    We emphatically demonstrate the role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.
    Cryptochlorogenic acid

    Catalog No: CFN99117
    CAS No: 905-99-7
    Price: $128/20mg
    Ononin

    Catalog No: CFN99136
    CAS No: 486-62-4
    Price: $148/20mg
    Sophoraflavanone G

    Catalog No: CFN92005
    CAS No: 97938-30-2
    Price: $138/20mg
    (+)-Lyoniresinol 9'-O-glucoside

    Catalog No: CFN97964
    CAS No: 87585-32-8
    Price: $418/5mg
    Dehydrotrametenolic acid

    Catalog No: CFN90577
    CAS No: 29220-16-4
    Price: $268/20mg
    Astrasieversianin VII

    Catalog No: CFN90648
    CAS No: 86764-11-6
    Price: $268/10mg
    Isomucronulatol 7-O-glucoside

    Catalog No: CFN93256
    CAS No: 94367-43-8
    Price: $238/10mg
    4,5-Di-O-caffeoylquinic acid methyl ester

    Catalog No: CFN90858
    CAS No: 188742-80-5
    Price: $388/5mg
    Gelidoside

    Catalog No: CFN89019
    CAS No: 128420-44-0
    Price: $288/10mg
    2''-O-Galloylquercitrin

    Catalog No: CFN95041
    CAS No: 80229-08-9
    Price: $418/5mg