Rosiridin
Rosiridin has cardioprotective activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Xinjiang Medical University,2007, 30(2):127-9.
The determination of rosiridin in effect extracts of anti-coronary atherosclerotic heart disease of Rhodiola rosea by HPLC[Reference:
WebLink]
To develop an assay method for determining the concentrations of Rosiridin in effect extracts of anti-coronary atherosclerotic heart disease of Rhodiola rosea.
METHODS AND RESULTS:
High performance liquid chromatography detection (HPLC) was used, using a ODS C18 column (250 mm×4.6 mm, 5 μm) set at 35℃, methanol-water (35∶65) as mobile phase with flowing rate 0.8 ml/min and detected at 210 nm. The linear range of Rosiridin was 5.5~550 μg/ml (r=0.999 6), and the average recovery (n=9) was 98.5%, RSD=1.3%.
CONCLUSIONS:
This method is simple, accurate and reproducible. It provides a basis for the quality evaluation for effect extracts of anti-coronary atherosclerotic heart disease of Rhodiola rosea.
Chem Pharm Bull (Tokyo). 2008 May;56(5):695-700.
Reinvestigation of absolute stereostructure of (-)-rosiridol: structures of monoterpene glycosides, rosiridin, rosiridosides A, B, and C, from Rhodiola sachalinensis.[Pubmed:
18451561]
Three new (-)-rosiridol glycosides, rosiridosides A, B, and C, were isolated from the roots of Rhodiola sachalinensis together with Rosiridin [(-)-rosiridol 1-O-beta-D-glucopyranoside]. In the course of the structure elucidation of those new glycosides, the absolute configuration of the 4-position in (-)-rosiridol was reinvestigated. On the basis of the application of the modified Mosher's method for (-)- and (+)-rosiridol derivatives, the absolute configuration of the 4-position in (-)-rosiridol should be revised to be S orientation from the recently assigned R form, so that the absolute stereostructures of rosiridosides A, B, and C and Rosiridin were determined.
