Roburic acid

Roburic acid
Product Name Roburic acid
CAS No.: 6812-81-3
Catalog No.: CFN98562
Molecular Formula: C30H48O2
Molecular Weight: 440.71 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: White powder
Targets: COX
Source: The roots of Gentiana macrophylla
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $158/20mg
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Eur J Pharmacol.2020, 889:173589.
  • Chemistry of Plant Materials.2016, 33-46
  • Chinese Pharmaceutical Journal2023, 58(2):178-187.
  • Applied Biological Chemistry2022, 65(12)
  • iScience.2023, 26(9):107602.
  • Food Res Int.2024, 191:114613.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Eur J Pharmacol.2024, 975:176644.
  • Mol Biol Rep.2022, doi: 10.1007
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