Roburic acid
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J Pharmaceutical and Biomedical Analysis2022, 114631.
Eur J Pharmacol.2020, 889:173589.
Chemistry of Plant Materials.2016, 33-46
Chinese Pharmaceutical Journal2023, 58(2):178-187.
Applied Biological Chemistry2022, 65(12)
iScience.2023, 26(9):107602.
Food Res Int.2024, 191:114613.
Evid Based Complement Alternat Med.2020, 2020:8582318.
Eur J Pharmacol.2024, 975:176644.
Mol Biol Rep.2022, doi: 10.1007
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Pharmacol Res. 2010 Jun;61(6):519-24.
Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.[Pubmed:
20188172]
METHODS AND RESULTS:
Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) using pulsed ultrafiltration liquid chromatography-mass spectrometry, and a mass spectrometry-based enzyme assay was used to determine the concentration of each of 17 ligands that inhibited COX-1 or COX-2 by 50% (IC(50)). Acetyl-11-keto-beta-boswellic acid, beta-boswellic acid, acetyl-alpha-boswellic acid, acetyl-beta-boswellic acid, and betulinic acid were COX-1 selective inhibitors with IC(50) values of approximately 10 microM. Senkyunolide O and cryptotanshinone were COX-2 selective inhibitors with IC(50) values of 5 microM and 22 microM, respectively.
CONCLUSIONS:
Roburic acid and phenethyl-trans-ferulate inhibited COX-1 and COX-2 equally. COX inhibition and the IC(50) values of most of these natural product ligands have not been reported previously.
Zhongguo Zhong Yao Za Zhi. 2005 Oct;30(19):1519-22.
Studies on the chemical constituents in root of Gentiana macrophylla from Shaanxi[Pubmed:
16335823]
To in vestigate the constituents in root of Gentiana macrophylla.
METHODS AND RESULTS:
Various column chromatographic techniques were used for isolation and purification of the principles. The structures were elucidated on the basis of spectral data (UV, IR, MS, 1H-, 13C-NMR etc.) and identified by comparing with standard substance. Eight compounds were identified. Four compounds isolated from the chloroform fraction are: 5-carboxyl-3,4-dihydrogen-1H-2-benzopyran-1-one (1), erythrocentauric acid (2), Roburic acid (3), oleanolic acid (4). Water fraction gave four known secoiridoid glucosides. They were: gentiopicroside (5), swertiamarine (6), sweroside (7), 6'-O-beta-D-glucosylgentiopicroside (8).
CONCLUSIONS:
1 is a novel compound. It was named as erythrocentauric acid. 2 was isolated from genus Gentiana and 8 was isolated from G. macrophylla for the first time.
