3-O-Acetyl-11-keto-beta-boswellic acid
3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Toxicol Mech Methods. 2006;16(4):199-226.
Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).[Pubmed:
20021046]
The novel anti-inflammatory properties of the gum resin derived from Boswellia serrata, also known as Salai guggal in Ayurvedic medicine, are well recognized and highly recommended for human consumption. The active constituents of the gum resin are boswellic acids (BAs). Among the BAs, 3-O-Acetyl-11-keto-beta-boswellic acid potently inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.
CONCLUSIONS:
We developed a novel Boswellia serrata extract (5-Loxin(R)) enriched with 30% 3-O-Acetyl-11-keto-beta-boswellic acid (US Patent 2004/0073060A1).
Biomed Chromatogr. 2014 Oct;28(10):1402-8.
Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC-MS.[Pubmed:
24806456]
11-keto-β-boswellic acid and 3-O-Acetyl-11-keto-beta-boswellic acid following oral administration of HLXLD or Boswellia serrata extract alone in normal and arthritic rats.
METHODS AND RESULTS:
An LC-MS method was developed and validated for the determination of 11-keto-β-boswellic acid and 3-O-Acetyl-11-keto-beta-boswellic acid in the comparative pharmacokinetic study. The results showed that there were significant differences in pharmacokinetic parameters between normal and arthritic groups. Interestingly, the absorptions of two boswellic acids were significantly higher in HLXLD than Boswellia serrata extract alone, indicating the synergistic effect of other herbal ingredients in HLXLD.
CONCLUSIONS:
This comparative pharmacokinetic study provided direct evidence supporting the notion that the efficacy of a complex mixture such as HLXLD is better than that of single components in treating human diseases.
