Puerol A exhibits potent inhibitory effects on aldose reductase with IC50 values of 6.4 uM. dl-Puerol A has antioxdiant activity, it shows inhibitory effects on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Inhibitory effects of dl-Puerol A in the root of Sophora japonica on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro[Reference: WebLink
METHODS AND RESULTS:
The inhibitory effect of dl-Puerol A as but-2-enolide isolated from Sophora japonica was investigated on copper ion-induced protein oxidative modification in vitro. It inhibited copper-induced protein oxidative modification. However, its inhibitory effect was a little weaker than that of as an antioxidant.
The results demonstrated that dl-Puerol A, one of but-2-enolides, might be of use in the oxidative stress.
Arch Pharm Res. 2010 Aug;33(8):1165-8.
A new isoflavone glycoside from the stem bark of Sophora japonica.[Pubmed: 20803118
METHODS AND RESULTS:
A new isoflavone glycoside, 6-methoxy-7-hydroxy-4'-O-beta-D-glucosyl isoflavone, glycitein-4'-O-beta-D-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory effects of all the isolated compounds on aldose reductase were evaluated in vitro.
Among these compounds, daidzein (1), Puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC(50) values of 3.2, 6.4, and 1.9 microM, respectively.