Polygalasaponin XXXI
Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a prolongation effect on hexobarbital sleeping time in mice. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) can inhibit proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Acta Horticulturae, 2005 , 679 (679) :121-129.
Intranasally and orally effective adjuvants from Chinese and Japanese medicinal herbs for nasal influenza vaccine[Reference:
WebLink]
Active substances from hot water extracts from 267 different Chinese and Japanese medicinal herbs were screened for mucosal adjuvant activity with influenza HA vaccine in mice.
The extract from the root of Polygala tenuifolia was found to contain potent mucosal adjuvant activity.
METHODS AND RESULTS:
The active substances were purified and identified as onjisaponins A, E, F and G. Two inoculations of mice with onjisaponin F ((Polygalasaponin XXXI,1 μg) and influenza HA vaccine (1 μg) at 3 weeks intervals, significantly increased serum HI antibody and nasal anti-influenza virus IgA and IgG antibody titers after only 1 week over mice given HA vaccine alone after the secondary vaccination. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) inhibited proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice. Onjisaponins also showed adjuvant effect for intranasal vaccination of diphtheria-pertussis-tetanus (DPT) vaccine.
CONCLUSIONS:
Traditional Japanese herbal (Kampo) formulation, Sho-seiryu-to (Xiao-Qing-Long-Tang in Chinese) showed oral adjuvant activity for nasally administered influenza vaccine.
Chemical & Pharmaceutical Bulletin, 1982 , 30 (6) :2020-2024.
Inhibitors of cyclic adenosine monophosphate phosphodiesterase in Polygala tenuifolia[Reference:
WebLink]
Cyclic adenosine monophosphate (AMP) phosphodiesterase inhibitors contained in Polygala tenuifolia WILLD. were identified as saponins and oleic acid. The concentrations of onjisaponins E, F and G required to give 50% inhibition (IC 50) were of the sameor der as that of papaverine.
METHODS AND RESULTS:
A kinetic study revealed that onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine. Onjisaponin F(Polygalasaponin XXXI) exhibited a prolongation effect on hexobarbital sleeping time in mice.
