Periplocoside M
Periplocoside M possesses observably antitumor activity against SMMC-7721( IC 50=12.9 ng/L),Hela( IC 50=8.63 ng/L) and MCF-7( IC 50=18.5 ng/L) cancer cell lines.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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China Journal of Chinese Medicine, 2014.
Study on Antitumor Activity and Structure-activity Relationship of C21 Steroids from Periplocae Cortex[Reference:
WebLink]
To investigate the antitumor activity of five C21 steroids and illuminate the structure-activity relationship.
METHODS AND RESULTS:
MTT assay was firstly used to explore the cytotoxic activity against three cancer cell lines in vitro of compound 1- 5 isolated from Periplocae Cortex. Among the five compounds,compound 1 possessed observably antitumor activity against SMMC-7721( IC 50 12. 9 ng·L- 1),Hela( IC 50 8. 63 ng·L- 1) and MCF-7( IC 50 18. 5 ng·L- 1) cancer cell lines.
CONCLUSIONS:
Compound 1( Periplocoside M) possessed observably cytotoxic activity.
The SAR of the five compounds indicated that C-3 was an important position for keeping the cytotoxic activity of C21 steroids from Periplocae Cortex.
Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(15):2286-8.
A new cardiac glycoside from Periploca forrestii.[Pubmed:
23189735]
To study the chemical constituents of Periploca forrestii.
METHODS AND RESULTS:
The constituents were separate using such various column chromatographic techniques as silica gel, RP-18 silica gel, MCI and Sephadex LH-20. Their structures were identified by such methods as spectral analysis. Ten compounds were isolated and identified as periforgenin A-3-O-beta-digitoxopyranoside (1), beta-sitosterol (2), periforoside I (3), ursolic acid (4), periplogenin (5), periplocin (6), glycoside E (7), Periplocoside M (8) , daucosterol (9), 2alpha, 3alpha, 23-trihydroxy-urs-12-en-28-oic acid (10).
CONCLUSIONS:
Compound 1 was a new cardiac glycoside and compound 8 was reported for the first time from this plant.
