Ophiopogonanone A
Ophiopogonanone A has oxygen free radicals(OFRs) scavenging effects, it can scavenge hydroxyl radical(·OH) and hydrogen peroxide(H2O2) in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Journal of Natural Medicines,2008,6(3):201-4.
Homoisoflavonoids from Ophiopogon japonicus and Its Oxygen Free Radicals(OFRs) Scavenging Effects[Pubmed:
12444717]
To investigate the OFRs scavenging activities of homoisoflavonoids from the fibrous root of Ophiopogon japonicus.
METHODS AND RESULTS:
The scavenging effect of homoisoflavonoids isolated from O.japonicus extracts was examined on superoxide anion(O2·-),hydroxyl radical(·OH),and hydrogen peroxide(H2O2) by chemiluminescence. Ten homoisoflavonoids were obtained from O.japonicus extracts.They were identified as methylOphiopogonanone A(1),methylophiopogonanone B(2),Ophiopogonanone A(3),ophiopogonanone E(4),5,7-dihydroxy-6,8-dimethyl-3-(4'-hydroxy-3',5'-methoxybenzyl) chroman-4-one(5),methylophiopogonone A(6),methylophiopogonone B(7),desmethylisoophiopogonone B(8),5,7,2'-trihydroxy-8-methyl-3-(3',4'-methylenedioxybenzyl) chromone(9) and 5,7,2'-trihydroxy-6,8-dimethyl-3-(3',4'-methylenedioxybenzyl) chromone(10).
CONCLUSIONS:
Compounds 8 and 9 were firstly isolated from O.japonicus.The majority of homoisoflavonoids could scavenge ·OH and H2O2 in vitro to a certain extent,and their bioactivities should be related with the respective structures.
Chemical & Pharmaceutical Bulletin, 2008,28(7):2039-44.
Studies on the Constituents of Ophiopogonis Tuber. VI. Structures of Homoisoflavonoids. (2)[Reference:
WebLink]
METHODS AND RESULTS:
New homoisoflavonoidal compounds, ophiopogonone A (Va), isoophiopogonone A (VIa), ophiopogonone B (VIIa), desmethylisoophiopogonone B (VIII) and Ophiopogonanone A (IXa) were isolated as constitutents of Ophiopogonis tuber (Ophiopogon japonicus KER-GAWLER var. genuinus MAXIM., Liliaceae), and their chemical structures were elucidated as 5, 7-dihydroxy-6-methyl-3-(3, 4-methylenedioxybenzyl) chromone, 5, 7-dihydroxy-8-methyl-3-(3, 4-methylenedioxybenzyl) chromone, 5, 7-dihydroxy-6-methyl-3-(4-methoxybenzyl) chromone, 5, 7-dihydroxy-8-methyl-3-(4-hydroxybenzyl) chromone and 5, 7-dihydroxy-6-methyl-3-(3, 4-methylenedioxybenzyl) chroman-4-one, respectively, by chemical and spectral studies.
