Methylophiopogonanone A
Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties, it also has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulating the expression of MMP-9 and tight junction proteins.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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PLoS One. 2015 Apr 21;10(4):e0124558.
Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro.[Pubmed:
25897666]
Methylophiopogonanone A (MO-A), an active homoisoflavonoid of the Chinese herb Ophiopogon japonicus which has been shown to have protective effects on cerebral ischemia/reperfusion (I/R) injury, has been demonstrated to have anti-inflammatory and anti-oxidative properties. However, little is known about its role in cerebral I/R injury.
METHODS AND RESULTS:
Therefore, in this study, by using a middle cerebral artery occlusion (MCAO) and reperfusion rat model, the effect of MO-A on cerebral I/R injury was examined. The results showed that MO-A treatment reduced infarct volume and brain edema, improved neurological deficit scores, reversed animal body weight decreases, and increased animal survival time in the stroke groups. Western blotting showed that MO-A suppressed MMP-9, but restored the expression of claudin-3 and claudin-5. Furthermore, transmission electron microscopy were monitored to determine the blood-brain barrier (BBB) alterations in vitro. The results showed that MO-A markedly attenuated BBB damage in vitro. Additionally, MO-A inhibited ROS production in ECs and MMP-9 release in differentiated THP-1 cells in vitro, and suppressed ICAM-1 and VCAM-1 expression in ECs and leukocyte/EC adhesion.
CONCLUSIONS:
In conclusion, our data indicate that MO-A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulating the expression of MMP-9 and tight junction proteins.
Chinese Traditional & Herbal Drugs, 2015, 46(20):3091-5.
Comparison on homoisoflavones extracted from Ophiopogon japonicus in Sichuan and Zhejiang and their anti-oxidative activity.[Reference:
WebLink]
To compare the contents of three homoisoflavones and their anti-oxidative activity of Ophiopogon japonicus in Sichuan(OJS) and Zhejiang(OJZ).
METHODS AND RESULTS:
The determination was performed on ACQUITYTM UPLC BEH C18 column(100 mm × 2.1 mm, 1.7 μm), the Ultra Performance Liquid Chromatography-Photo-Diode Array(UPLC-PDA) technology was applied, and the mobile phase consisted of acetonitrile and 0.2% formic acid aqueous solution(55 : 45) with gradient elution program, flow rate was 0.20 m L/min with 2 μL of sample quantity at 296 nm, and the anti-DPPH radical efficiency of water extract from Ophiopogonis Radix were evaluated by UV-photometer. The average values of methylophiopogonone A, Methylophiopogonanone A, and methylophiopogonanone B were(3.06 ± 0.54),(40.10 ± 5.63), and(29.51 ± 5.06) μg/g in OJS, respectively; while those in OJZ were(9.22 ± 3.52),(106.63 ± 27.56), and(256.97 ± 61.79) μg/g, separately. The IC50 value was 16.59 mg/m L in OJS, while that in OJZ was 14.48 mg/m L. The IC50 value of positive control VC was 7.06 μg/m L.
CONCLUSIONS:
Compared with OJS, the contents of homoisoflavones in OJZ are higher, and the anti-radical efficiency of water extract from OJZ is stronger. It provides the basis for the quality evaluation and geo-authentic research of Ophiopogonis Radix.
