Ophiopogonanone E

Chinese Journal of Natural Medicines,2008,6(3):201-4.

Homoisoflavonoids from Ophiopogon japonicus and Its Oxygen Free Radicals(OFRs) Scavenging Effects[Pubmed: 12444717]

To investigate the OFRs scavenging activities of homoisoflavonoids from the fibrous root of Ophiopogon japonicus.
METHODS AND RESULTS:
The scavenging effect of homoisoflavonoids isolated from O.japonicus extracts was examined on superoxide anion(O2·-),hydroxyl radical(·OH),and hydrogen peroxide(H2O2) by chemiluminescence.Ten homoisoflavonoids were obtained from O.japonicus extracts.They were identified as methylophiopogonanone A(1),methylophiopogonanone B(2),ophiopogonanone A(3),Ophiopogonanone E(4),5,7-dihydroxy-6,8-dimethyl-3-(4'-hydroxy-3',5'-methoxybenzyl) chroman-4-one(5),methylophiopogonone A(6),methylophiopogonone B(7),desmethylisoophiopogonone B(8),5,7,2'-trihydroxy-8-methyl-3-(3',4'-methylenedioxybenzyl) chromone(9) and 5,7,2'-trihydroxy-6,8-dimethyl-3-(3',4'-methylenedioxybenzyl) chromone(10).
CONCLUSIONS:
Compounds 8 and 9 were firstly isolated from O.japonicus.The majority of homoisoflavonoids could scavenge ·OH and H2O2 in vitro to a certain extent,and their bioactivities should be related with the respective structures.

J Nat Prod. 2002 Nov;65(11):1731-3.

Five new homoisoflavonoids from the tuber of Ophiopogon japonicus[Pubmed: 12444717]

METHODS AND RESULTS:
Five new homoisoflavonoids, ophiopogonanone C (1), ophiopogonanone D (2), ophiopogonone C (3), Ophiopogonanone E (4) and ophiopogonanone F (5), and six known compounds were isolated from an ethanol extract of the tubers of Ophiopogon japonicus (Thunb) Ker-Gawl. Spectroscopic analyses were used to elucidate the structures of these compounds.