Negundonorin A
Negundonorin A is strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 ug/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Fitoterapia. 2012 Jan;83(1):49-54.
Sesquiterpenoids and norterpenoids from Vitex negundo.[Pubmed:
21968063 ]
METHODS AND RESULTS:
Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, Negundonorin A (3) and negundonorin B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data.
CONCLUSIONS:
Compound 3 was strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 μg/mL, whereas compound 1 was most active against HL-60 cell line with IC(50) value of 0.94 ± 0.26 μg/mL.
