2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
Product Name 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
CAS No.: 176983-21-4
Catalog No.: CFN89112
Molecular Formula: C30H46O5
Molecular Weight: 486.69 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: HIV
Source: The leaves of Eriobotrya japonica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay of two-stage carcinogenesis on mouse skin.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Biomol Struct Dyn.2023, 1-21.
  • bioRxiv - Biochemistry2023, 541790.
  • Molecules.2021, 26(18):5665.
  • Environ Toxicol.2024, tox.24246
  • Materials Today Communications2023, 37:107216
  • Plant Sci.2020, 301:110656.
  • Int J Biol Macromol.2020, 169:342-351
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
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    Phytochemistry. 2002 Feb;59(3):315-23.
    Production of bioactive triterpenes by Eriobotrya japonica calli.[Pubmed: 11830140]

    METHODS AND RESULTS:
    Callus tissue cultures induced from an axenic leaf of Eriobotrya japonica (Rosaceae) produced triterpenes in large amounts (ca. 50 mg/g dry wt). Nine triterpenes were characterized as ursolic acid, oleanolic acid, 2alpha-hydoxyursolic acid, maslinic acid, tormentic acid, 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid, hyptadienic acid and a mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid. The triterpene composition in the callus tissues was noticeably different from that in intact leaves. The contents of tormentic acid with antidiabetic action, and 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid with anti-HIV activity, were much larger than those in the intact leaves.
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