Methyl demethoxycarbonylchanofruticosinate
Methyl demethoxycarbonylchanofruticosinate exhibits significant antitussive activity in a citric acid induced guinea pig cough model.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Med. 2011 Jun;77(9):939-44.
Antitussive indole alkaloids from Kopsia hainanensis.[Pubmed:
21165819]
METHODS AND RESULTS:
Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and Methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and Methyl demethoxycarbonylchanofruticosinate exhibited significant antitussive activity in a citric acid induced guinea pig cough model.
CONCLUSIONS:
The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor.This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.
