Lauterine
Lauterine is a DNA topoisomerase inhibitor.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Molecules2022, 27(9):2992.
Free Radic Biol Med.2021, 166:104-115.
Chin. Med.J.Res. Prac.2017, 31(4)
JPC-Journal of Planar Chromatography 2017, 30(4)
bioRxiv2021, 462065.
Sci Rep.2024, 14(1):3684.
Bioorg Med Chem.2020, 28(12):115553.
J Control Release.2021, 336:159-168.
Front Pharmacol.2017, 8:673
Korean Journal of Pharmacognosy.2020, 51(2):100-106
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J Nat Prod. 1994 Jan;57(1):68-73.
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.[Pubmed:
8158166]
METHODS AND RESULTS:
The oxoaporphine alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae).
Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3], O-methylmoschatoline [4], and lysicamine [5], were also isolated from this plant. Selective toxicity was also observed for 10-methoxyliriodenine (Lauterine) [6] and 10-hydroxyliriodenine [7], two oxoaporphine alkaloids isolated from Miliusa cf. banacea (Annonaceae). The structure of 10-hydroxyliriodenine [7], a novel oxoaporphine, was determined by spectroscopic methods and chemical conversion to compound 6.
CONCLUSIONS:
The role of the bioactive oxoaporphine alkaloids as DNA topoisomerase inhibitors is discussed.
Lloydia, 1977, 40(2):152-156.
Isolation of lauterine and oxoputerine, two new oxoaporphine alkaloids from Guatteria elata[Reference:
WebLink]
METHODS AND RESULTS:
Two new oxoaporphine alkaloids, Lauterine (1) and oxoputerine (4), were isolated from Guatteria elata R. E. Fries (Annonaceae). The structures of these alkaloids were established by interpretation of their uv, ir, pmr, and mass spectra, and by their transformation to laureline and pukateine methyl ether respectively.
CONCLUSIONS:
Oxoxylopine and lanuginosine were shown to be identical and therefore have the structure 2.
