Laurolitsine | CAS:5890-18-6 | Manufacturer ChemFaces

Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Natural Product Communications2020, doi: 10.1177.

Food Chem.2022, 378:131975.

Phytomedicine.2022, 100:154058.

Phytomedicine.2021, 83:153483.

J Lipid Res.2024, 65(10):100640.

Front Endocrinol (Lausanne).2023, 14:1138676.

Cancer Sci.2022, 113(4):1406-1416.

Phytother Res.2018, 32(12):2551-2559

Saf Health Work.2019, 10(2):196-204

Nutrients.2020, 12(11):3448.

J Nat Prod. 2013 Mar 22;76(3):405-12.

Semisynthesis and myocardial activity of thaliporphine N-homologues.[Pubmed: 23305495]

The N-homologues and optical isomers of thaliporphine (5a), a potent antiarrhythmic agent, were prepared starting from Laurolitsine (1), an abundant aporphine present in Phoebe formosana.
METHODS AND RESULTS:
Treating N-propylnorglaucine with 90% H2SO4 yielded one additional product, an 11-sulfonyl-1,11-anhydroaporphine. Reaction of N-formylnorglaucine (3a) with 90% H2SO4, however, yielded the 9-sulfonyl-seco product as a major product. Treatment of 3a with 98% H2SO4 yielded pancordine (10), which, upon catalytic hydrogenation, yielded (±)-wilsonirine. (1)H NMR spectroscopic analysis was applied successfully to monitor the optical purity of the crystalline salt while undertaking optical resolution.
CONCLUSIONS:
Thaliporphine (5a) was demonstrated to possess better positive inotropic and less negative chronotropic effects than the left-hand optical isomer and showed the best activity on rat cardiac tissue among the N-homologues prepared.

Product Name	Laurolitsine
CAS No.:	5890-18-6
Catalog No.:	CFN90492
Molecular Formula:	C₁₈H₁₉NO₄
Molecular Weight:	313.34 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The roots of Lindera aggregata (Sims) Kosterm
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: