L-Aspartic acid
L-Aspartic acid induces a region of negative slope conductance in the current-voltage relationship of cultured spinal cord neurons. It could as the amino donor.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
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Brain Research, 1982, 237(1):248-253.
L-aspartic acid induces a region of negative slope conductance in the current-voltage relationship of cultured spinal cord neurons.[Reference:
WebLink]
Individual murine spinal cord neurons were grown in dissociated tissue cultures.
METHODS AND RESULTS:
Using either one or two conventional intracellular microelectrodes neurons were voltage-clamped and current-voltage (I–V) curves were constructed using command pulses.L-Aspartic acid was then applied and I–V curves repeated in the presence of this excitatory amino acid.L-Aspartic acid induced a region of negative slope conductance (RNSC) in the steady-state I–V relationships of these neurons.
CONCLUSIONS:
Such a RNSC accounts for the apparent reduction of conductance observed in response to excitatory amino acids5,7,8 and its instability likely contributes to the electrogenesis of bursting in central neurons.
Enzyme & Microbial Technology, 2000, 27( 1–2):19-25.
Selective production of L-aspartic acid and L-phenylalanine by coupling reactions of aspartase and aminotransferase in Escherichia coli.[Reference:
WebLink]
METHODS AND RESULTS:
With l-aspartate (L-Asp) as the amino donor, l-phenylalanine (L-Phe) can be prepared from phenylpyruvate (PPA) via an amination reaction mediated by aminotransferase (encoded by aspC). On the other hand, L-Asp can be produced by an aspartase (encoded by aspA) -catalyzed reaction using fumaric acid as substrate. To overproduce aspartase in Escherichia coli, the aspA gene was cloned and overexpressed 180 times over the wild-type level. The use of AspA-overproducing E. coli strain for L-Asp production exhibited an 83% conversion, approaching to the theoretical yield, whereas the wild-type strain obtained scarcely L-Asp. Furthermore, the recombinant strain overproducing both AspA and AspC was able to produce L-Asp and L-Phe simultaneously by using fumaric acid and PPA as substrates. As a result, the conversion yields obtained for L-Asp and L-Phe were 78% and 85%, respectively. In sharp contrast, the wild-type strain attained a conversion of L-Phe less than 15% and an undetectable level of L-Asp.
CONCLUSIONS:
This result illustrates a potential and attractive process to yield both L-Asp and L-Phe by coupling AspA and AspC. A further study on the repeated use of the recombinant strain immobilized with calcium alginate showed that after eight batch runs L-Asp conversion maintained roughly constant (around 75%), whereas L-Phe conversion dropped to 65% from 81%. This result indicates the stability of AspA being superior to AspC.
