Jaceidin
Jaceidin demonstrates modest antioxidant activity, in a dose-dependent manner.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Fitoterapia. 2004 Dec;75(7-8):629-33.
Antiplatelet activity of Varthemia iphionoides.[Pubmed:
15567236]
METHODS AND RESULTS:
Aqueous and alcoholic extracts, volatile oil and four flavonoids, xanthomicrol (1), kumatokenin (2), Jaceidin (3) and 3, 3'-di-O-methylquercetin (4), isolated from Varthemia iphionoides were investigated for their in vitro anti-platelet activity. Aqueous extract and compounds (1), (2) and (4) showed anti-platelet activity.
Volatile oil and the alcoholic extract did not exhibit any anti-platelet activity.
CONCLUSIONS:
Structures of the isolated compounds (1)-(4) were determined by spectroscopic methods (UV, IR, MS, (1)H-NMR).
Nat Prod Commun. 2010 May;5(5):729-32.
Protective effect on human lymphocytes of some flavonoids isolated from two Achillea species.[Pubmed:
20521537]
This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), Jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes.
METHODS AND RESULTS:
Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 microg/mL) gave a 35.5% decrease in the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 microg/mL and 10 microg/mL) seemed less effective. Flavonoid 5 (3 microg/mL) induced a slight decrease in MN frequency (5%), while higher doses (6 microg/mL and 10 microg/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation.
CONCLUSIONS:
In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.
