Isorosmanol
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentation.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Med Food.2020, 23(6):633-640.
Plants (Basel).2021, 10(2):278.
Molecules.2023, 28(9):3685.
J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
Phytomedicine.2019, 67:153159
Applied Biological Chemistry2020, 63:33(2020)
Phytomedicine.2024, 126:155442.
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Phytomedicine. 2016 Sep 15;23(10):1005-11.
Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis.[Pubmed:
27444345]
Salvia officinalis is a traditionally used herb with a wide range of medicinal applications. Many phytoconstituents have been isolated from S. officinalis, mainly phenolic diterpenes, which possess many biological activities. This study aimed to evaluate the ability of the phenolic diterpenes of S. officinalis to inhibit acetylcholine esterase (AChE) as well as their ability to inhibit melanin biosynthesis in B16 melanoma cells.
METHODS AND RESULTS:
The phenolic diterpenes isolated from the aerial parts of S. officinalis were tested for their effect on melanin biosynthesis in B16 melanoma cell lines. They were also tested for their ability to inhibit AChE using Ellman's method. Moreover, a molecular docking experiment was used to investigate the binding affinity of the isolated phenolic diterpenes to the amino acid residues at the active sites of AChE. Seven phenolic diterpenes-sageone, 12-methylcarnosol, carnosol, 7b-methoxyrosmanol, 7a-methoxyrosmanol, Isorosmanol and epirosmanol-were isolated from the methanolic extract of the aerial parts of S. officinalis. Isorosmanol showed a melanin-inhibiting activity as potent as that of arbutin. Compounds 7a-methoxyrosmanol and Isorosmanol inhibited AChE activity by 50% and 65%, respectively, at a concentration of 500 μM.
CONCLUSIONS:
The results suggest that Isorosmanol is a promising natural compound for further studies on development of new medications which might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentation.
J Agric Food Chem. 2002 Mar 27;50(7):1845-51.
Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method.[Pubmed:
11902922]
METHODS AND RESULTS:
A new abietane diterpenoid, 12-O-methyl carnosol (2), was isolated from the leaves of sage (Salvia officinalis L.), together with 11 abietane diterpenoids, 3 apianane terpenoids, 1 anthraquinone, and 8 flavonoids.
Antioxidant activity of these compounds along with 4 flavonoids isolated from thyme (Thymus vulgaris L.) was evaluated by the oil stability index method using a model substrate oil including methyl linoleate in silicone oil at 90 degrees C. Carnosol, rosmanol, epirosmanol, Isorosmanol, galdosol, and carnosic acid exhibited remarkably strong activity, which was comparable to that of alpha-tocopherol. The activity of miltirone, atuntzensin A, luteolin, 7-O-methyl luteolin, and eupafolin was comparable to that of butylated hydroxytoluene.
CONCLUSIONS:
The activity of these compounds was mainly due to the presence of ortho-dihydroxy groups. The 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of these compounds showed the similar result.
Z Naturforsch C. 2009 May-Jun;64(5-6):395-8.
Neuroprotective and neurotrophic effects of isorosmanol.[Pubmed:
19678545]
The neurotoxicity induced by beta-amyloid (Abeta), which is one of the major causes of Alzheimer's disease (AD), leads to synaptic loss and subsequent neuronal death. Therefore, modulation of Abeta-induced neurotoxicity, as well as regeneration of damaged synapses could be important therapeutic approaches to control AD.
METHODS AND RESULTS:
In this study, we found that Isorosmanol, an abietane-type diterpene, protected PC12 cells against Abeta-induced toxicity. Furthermore, Isorosmanol promoted the generation of neurites. The neurotrophic effect of Isorosmanol was enhanced by co-treatment with nerve growth factor (NGF). In addition, the neurite outgrowth induced by Isorosmanol was accompanied by F-actin redistribution and increased expression of neurofilaments.
CONCLUSIONS:
Taken together, these results suggest that Isorosmanol possesses both neuroprotective and neurotrophic effects, that might be beneficial for controlling AD.
