Securoside A

Zhongguo Zhong Yao Za Zhi . 2021 Mar;46(5):1160-1167

Research on chemical constituents from Artemisia annua[Pubmed: 33787111]

Chemical constituents were isolated and purified from the water extract of Artemisia annua by column chromatography of HP-20 macroporous resin, silica gel, ODS, Sephadex LH-20, HW-40, and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. As a result, Fifteen compounds were isolated and identified as vitexnegheteroin M(1), sibricose A5(2), Securoside A(3), citrusin D(4), annphenone(5), E-melilotoside(6), esculetin(7), scopoletin-7-O-β-D-glucoside(8), eleutheroside B_1(9), chrysosplenol D(10), patuletin-3-O-β-D-glucopyranoside(11), quercetin-7-O-β-D-glucoside(12), rutin(13), apigenin 6,8-di-C-β-D-glucopyranoside(14), isoschaftoside(15), among them, compounds 1-4 were identified from Artemisia for the first time. Additionally, the isolates were evaluated for their inhibitory effects on the production of PGE_2 in LPS-simulated RAW264.7 macrophages. The results showed that compounds 1, 2, 8, and 10-15 could reduce PGE_2 levels, to a certain extent.

Chemical Journal of Chinese Universities, 01 Jan 2003, 24(1):61-63

New Sucrose Esters from Securidaca Inappendiculata[Reference: WebLink]

Three sucrose esters, #beta#-D-(3,4-O-disinapoyl)fructofuranosyl-#alpha#-D-(6-O-sinapoyl)gluco-pyranoside(1), #beta#--D-(3-O-feruloyl)fructofuranosyl-#alpha#-D-(6-O-sinapoyl)glucopyrano-side(2), and #beta#-D-(3-O-feruloyl) fructofuranosyl-#alpha#-D-(6-O-feruloyl)glucopyranoside(3) were isolated from the stems of Securidaca inappendiculata collected from Yunnan Province. Among them, compound 3 was a new sucrose ester and was named as Securoside A . All structures were elucidated on the basis of chemical and spectroscopic evidence, especially ~(13)C, ~(1)M NMR and ESI-MS experiments.