Isodictamnine
Isodictamnine is phototoxic to certain bacteria and yeasts in long wave UV light.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Environ Toxicol.2024, tox.24246
Br J Pharmacol.2016, 173(2):396-410
Int J Mol Sci.2024, 25(6):3390.
Front Cell Dev Biol.2021, 9:764263.
Free Radic Biol Med.2016, 97:307-319
Neurotox Res.2020, 38(1):163-174.
Am J Chin Med.2023, 51(7):1675-1709.
Phytomedicine.2020, 79, 153351
The Japan Society for Analytical Chemistry2017, 613-617
Front Pharmacol.2024, 15:1439079.
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Planta Med. 1981 Feb;41(2):136-42.
Phototoxic furanoquinolines of the Rutaceae.[Reference:
WebLink]
METHODS AND RESULTS:
Dictamnine, Isodictamnine, 7-demethylskimmianine, maculosidine and maculine were shown to be phototoxic to certain bacteria and yeasts in long wave UV light. Dose response curves with dictamnine and 8-methoxypsoralen in UV light were compared using E. COLI and SACCHAROMYCES CEREVISIAE.
CONCLUSIONS:
In comparison with 8-methoxypsoralen higher concentrations of dictamnine are required to elicit a phototoxic response.
Chemistry of Natural Compounds, 1978, 14(4):404-406.
The roots of Dictamnus angustifolius.[Reference:
WebLink]
METHODS AND RESULTS:
From the roots of Dictamnus angustifolius G. Don. collected in Chimgan at the end-of-fruit-bearing stage have been isolated alkaloids dictamnine, skimmianine, γ-fagarine, Isodictamnine, isopteleine, and preskimmianine, the limonoid fraxinellone, and the steroid β-sitosterol.
CONCLUSIONS:
This is the first time that any of these substances, with the exception of dictamnine and skimmianine, have been found in this plant.
