Isopteleine
Isopteleine shows weak cytotoxic activities against human breast cancer cells (MCF7).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Biochem Mol Toxicol.2022, e23211.
Phytomedicine Plus2022, 2(1):100207.
Molecules.2023, 28(8):3291.
Biochem Biophys Res Commun.2020, 527(4):889-895.
LWT-Food Sci Technol2020, 109163
Eur J Pharm Sci.2016, 94:33-45
Korean Journal of Pharmacognosy.2020, 51(2):100-106
Food Quality and Safety2018, 2:213-219
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Chin J Nat Med. 2014 Mar;12(3):222-4.
A new quinoline alkaloid from the roots of Dictamnus angustifolius.[Pubmed:
24702810]
To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).
METHODS AND RESULTS:
The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis. A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), Isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7).
CONCLUSIONS:
Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.
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