Ingenol-3-palmitate shows irritant and cocarcinogenic activity on mouse ear and on mice back skin.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Tumor promoting constituent of Euphorbia serrata L. latex.[Pubmed: 971764
METHODS AND RESULTS:
Euphorbia serrata latex has initially Ingenol 3-palmitate, which by action of silica gel is converted to ingenol-20-palmitate.
The former is responsible for the irritant and cocarcinogenic activity of the latex on mouse ear and on mice back skin.