Ingenol 20-palmitate
Ingenol 20-palmitate is a natural product from Euphorbia sieboldiana.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Experientia. 1976 Sep 15;32(9):1196-7.
Tumor promoting constituent of Euphorbia serrata L. latex.[Pubmed:
971764]
METHODS AND RESULTS:
Euphorbia serrata latex has initially ingenol-3-palmitate, which by action of silica gel is converted to Ingenol 20-palmitate.
CONCLUSIONS:
The former is responsible for the irritant and cocarcinogenic activity of the latex on mouse ear and on mice back skin.
Planta Med. 1991 Dec;57(6):569-71.
New Diterpenoids from Euphorbia sieboldiana.[Pubmed:
17226204 ]
METHODS AND RESULTS:
From the acetone extract of roots of EUPHORBIA SIEBOLDIANA, three known diterpenes, ENT-atisane-3beta,16alpha,17-triol ( 1), ingenol ( 4), and helioscopinolide A ( 5) as well as two new diterpenes, 3beta- O-acetyl- ENT-atisane-16alpha,17-diol ( 2), and Ingenol 20-palmitate ( 3) were isolated.
CONCLUSIONS:
Their structures were elucidated by spectroscopic methods and chemical transformations.
