Helichrysetin
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Research Square2021, March 3rd.
Int J Mol Sci.2022, 23(23):15213.
J Ethnopharmacol.2021, 267:113615.
Biochem Biophys Res Commun.2020, 522(1):40-46
Biomed Pharmacother.2022, 145:112410.
Food Chem.2023, 427:136647.
J Pharmacopuncture.2023, 26(4):357-365.
Acta Agriculturae Scandinavica2015, 381-383
Natural Product Communications2020, doi: 10.1177.
Int J Mol Sci.2023, 24(5):4505.
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Bioorg Med Chem. 2006 Mar 15;14(6):1710-4.
Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata.[Pubmed:
16263298 ]
METHODS AND RESULTS:
Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity.
CONCLUSIONS:
Structure-activity relationships of these compounds on anti-HIV-1 PR activity are summarized as follows: (1) hydroxyl moiety at position 4 conferred higher activity than methoxyl group; (2) prenylation of dihydrochalcone was essential for activity; (3) hydroxylation at position 4''' reduced activity; and (4) introduction of double bond at C1' and C6' of chalcone gave higher activity. As regards active constituents contained in B. pandurata rhizomes, hydroxypanduratin A (3) and panduratin A (2) are active principles against HIV-1 PR.
Evid Based Complement Alternat Med. 2013;2013:857257.
Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells.[Pubmed:
23533528]
Researchers are looking into the potential development of natural compounds for anticancer therapy. Previous studies have postulated the cytotoxic effect of Helichrysetin towards different cancer cell lines.
METHODS AND RESULTS:
In this study, we investigated the cytotoxic effect of Helichrysetin, a naturally occurring chalcone on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29, and further elucidated its biochemical and molecular mechanisms in human lung adenocarcinoma, A549. Helichrysetin showed the highest cytotoxic activity against Ca Ski followed by A549. Changes in the nuclear morphology of A549 cells such as chromatin condensation and nuclear fragmentation were observed in cells treated with Helichrysetin. Further evidence of apoptosis includes the externalization of phosphatidylserine and the collapse of mitochondrial membrane potential which are both early signs of apoptosis.
CONCLUSIONS:
These signs of apoptosis are related to cell cycle blockade at the S checkpoint which suggests that the alteration of the cell cycle contributes to the induction of apoptosis in A549. These results suggest that Helichrysetin has great potentials for development as an anticancer agent.
J Nat Prod. 1989 May-Jun;52(3):629-33.
Isolation of flavonoids and a chalcone from Helichrysum odoratissimum and synthesis of helichrysetin.[Pubmed:
2778452]
METHODS AND RESULTS:
3,5-Dihydroxy-6,7,8-trimethoxyflavone, 3-O-methylquercetin, and Helichrysetin were isolated from the flowers of the Rwandese medicinal plant, Helichrysum odoratissimum.
Because of inconsistencies of the mp of the latter chalcone, a synthesis of Helichrysetin was developed.
CONCLUSIONS:
3-O-Methylquercetin was shown to be an active principle as it displayed antimicrobial activity.
