2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone
2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone can markedly augment TRAIL-induced apoptosis and cytotoxicity in LNCaP cells.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Journal of Phytopathology2021, 169,Issue11-12.
Plant Cell Physiol.2023, 64(7):716-728.
Agronomy2020, 10(3),388.
Bioorg Chem.2024, 145:107182.
Molecules.2019, 24(24),4583
Foods.2023, 12(6):1130.
Int J Oncol.2016, 49(4):1497-504
Natural Product Communications2022, 7(3):1-7.
Biomedicines.2024, 12(3):495.
J Agric Food Chem.2023, 71(47):18510-18523.
Related and Featured Products
Molecules (Basel, Switzerland), 04 Aug 2010, 15(8):5336-5353.
Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells.[Reference:
WebLink]
Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent.
We examined the cytotoxic and apoptotic effect of chalcones and dihydrochalcones on TRAIL-mediated apoptosis in LNCaP prostate cancer cells.
METHODS AND RESULTS:
The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was detected using annexin V-FITC by flow cytometry and fluorescence microscopy. The DeltaPsim was evaluated using DePsipher staining by fluorescence microscopy.
CONCLUSIONS:
Our study showed that two tested chalcones (chalcone and 2',6'dihydroxy-4'-methoxychalcone) and three dihydrochalcones (2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone, 2',6'-dihydroxy-4'-methoxydihydro- chalcone, and 2',4',6'-trihydroxydihydrochalcone, called phloretin) markedly augmented TRAIL-induced apoptosis and cytotoxicity in LNCaP cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.
