Griffithinam

Fitoterapia. 2011 Oct;82(7):964-8.

Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei.[Pubmed: 21641972]

METHODS AND RESULTS:
Bioassay-guided fractionation of the cytotoxic ethyl acetate extract from the stems of Dasymaschalon blumei (Annonaceae) led to the isolation of four aristololactam alkaloids, including the hitherto unknown 3,5-dihydroxy-2,4-dimethoxyaristolactam (1), as well as the three known compounds, aristolactam BI, goniopedaline, and Griffithinam. Additionally, the cytotoxic extract from the combined leaves and twigs of the same plant yielded three known oxoaporphine alkaloids, oxodiscoguattine, dicentrinone, and duguevalline. The structures of aristolactams and oxoaporphine alkaloids were elucidated on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a panel of mammalian cancer cell lines and a noncancerous human embryonic kidney cell Hek 293.

J Nat Prod. 1999 Jul;62(7):1050-2.

Alkaloids from the roots of goniothalamus griffithii.[Pubmed: 10425141]

METHODS AND RESULTS:
Three new alkaloids-griffithazanone A (1), griffithdione (2), and Griffithinam (3)-were isolated from the roots of Goniothalamus griffithii, along with six known compounds, 4-methyl-2,9, 10-(2H)-1-azaanthracenetrione (4), velutinam, aristololactam BI, aristololactam BII, aristololactam AII, and norcepharanone B. Their structures were elucidated on the basis of spectral and chemical methods.
CONCLUSIONS:
The absolute configuration of griffithazanone A (1) was determined by the preparation of Mosher's esters.