Ginsenoside F3
Ginsenoside F3 has immunoenhancing activity by regulating production and gene expression of type 1,type 2 cytokines in murine spleen cells. It enhances the NF-kappaB DNA binding activity induced by ConA in murine spleen cells with 10 micromol/L.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Acta Pharmacol Sin. 2004 Dec;25(12):1671-6.
Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells.[Pubmed:
15569414]
To investigate the immunoenhancing activity of Ginsenoside F3 in murine spleen cells and explore its mechanism.
METHODS AND RESULTS:
The enhancing effect of Ginsenoside F3 on murine spleen cell proliferation was studied using [3H]thymidine incorporation assay. Effects of ginsenoside-F3 on the production of type 1 cytokines IL-2, IFN-gamma, and type 2 cytokines IL-4 and IL-10 from murine spleen cells were detected by ELISA method. Effects of Ginsenoside F3 on mRNA level of cytokines IL-4, IFN-gamma, and transcription factors T-bet and GATA-3 were evaluated by RT-PCR analysis. Effect of Ginsenoside F3 on NF-kappaB DNA binding activity in murine spleen cells was investigated by electrophoretic mobility shift assays (EMSA).
Ginsenoside F3 at 0.1-100 micromol/L not only promoted the murine spleen cell proliferation, but also increased the production of IL-2 and IFN-gamma, while decreased the production of IL-4 and IL-10 from murine spleen cells with the maximal effect at 10 micromol/L. RT-PCR analysis displayed that Ginsenoside F3 enhanced the IFN-gamma and T-bet gene expression and decreased IL-4 and GATA-3 gene expression. EMSA experiment showed that Ginsenoside F3 10 micromol/L enhanced the NF-kappaB DNA binding activity induced by ConA in murine spleen cells.
CONCLUSIONS:
Ginsenoside F3 has immunoenhancing activity by regulating production and gene expression of type 1 cytokines and type 2 cytokines in murine spleen cells.
Chem Pharm Bull (Tokyo). 2013;61(3):273-8.
Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4).[Pubmed:
23238233]
METHODS AND RESULTS:
Four new dammarane-type triterpenoid saponins such as chikusetsusaponin LM3 (1), chikusetsusaponin LM4 (2), chikusetsusaponin LM5 (3), chikusetsusaponin LM6 (4), and twenty known triterpenoid saponins such as ginsenoside Rb3 (5), ginsenoside Rc (6), ginsenoside Rd (7), ginsenoside Re (8), ginsenoside Rg1 (9), Ginsenoside F3 (10), ginsenoside F5 (11), ginsenoside F6 (12), chikusetsusaponin IVa (13), chikusetsusaponin V (14), chikusetsusaponin L5 (15), chikusetsusaponin L9a (16), chikusetsusaponin L9bc (17), chikusetsusaponin L10 (18), chikusetsusaponin FK2 (19), chikusetsusaponin FK6 (20), chikusetsusaponin FK7 (21), chikusetsusaponin FT1 (22), chikusetsusaponin LM1 (23), and chikusetsusaponin LM2 (24), were isolated from the leaves of Panax japonicus C. A. MEYER collected in Miyazaki prefecture, Japan.
CONCLUSIONS:
The structures of new chikusetsusaponins were elucidated on the basis of spectral and physicochemical evidences.
Nat Prod Commun. 2012 Apr;7(4):491-3.
New triterpenoid saponins from leaves of Panax japonicus (3). Saponins of the specimens collected in Miyazaki prefecture.[Pubmed:
22574450]
Two new dammarane-type triterpenoid saponins, chikusetsusaponin LM1 (1), chikusetsusaponin LM2 (2), and three known triterpenoid saponins, ginsenoside Re (3), ginsenoside Rg1 (4), Ginsenoside F3 (5), were isolated from the leaves of P. japonicus C. A. Meyer collected in Miyazaki prefecture, Japan. The structures of new chikusetsusaponins were elucidated on the basis of spectroscopic and physicochemical evidences.
