Notoginsenoside Fa
Notoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Pharmaceutical Journal2023, 58(2):178-187.
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Int Immunopharmacol. 2020, 83:106403.
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J. Nat. Prod., 2002, 65(9):1288-92.
Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.[Pubmed:
12350149]
METHODS AND RESULTS:
Four new dammarane-type saponins (1-4), named yesanchinosides G-J, together with nine ginsenosides (5-13) were isolated from Ye-Sanchi, the underground part of Panax japonicus collected in the south of Yunnan Province, China. Their structures were elucidated on the basis of spectroscopic and chemical methods.
CONCLUSIONS:
Ginsenosides Rb(1) and Rb(3) and notoginsenosides R(4) (6) and Notoginsenoside Fa (7) showed significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.
