Dimethylmatairesinol

Dimethylmatairesinol
Product Name Dimethylmatairesinol
CAS No.: 943989-68-2
Catalog No.: CFN97524
Molecular Formula: C19H20O9
Molecular Weight: 392.4 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Source: The herbs of Macaranga tanarius
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung carcinoma, MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma ).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • J Nat Prod.2022, doi: 10.1021
  • Sci Rep. 2017, 12953(7)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Univerzita Karlova2022, 173245.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • Drug Des Devel Ther.2020, 14:969-976.
  • ACS Omega.2022, 7(44):40009-40020.
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
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    Planta Med. 2003 Aug;69(8):733-8.
    A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.[Pubmed: 14531024]

    METHODS AND RESULTS:
    In the roots of Anthriscus sylvestris 12 different lignans were detected. Arctigenin, Dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in A. sylvestris. In the cell suspension cultures, which were initiated for this study, trace amounts of deoxypodophyllotoxin could be detected. With these cell suspension cultures we carried out feeding experiments using deoxypodophyllotoxin, yatein and, anhydropodorhizol.
    CONCLUSIONS:
    Yatein had a toxic effect on the cell cultures and was, like anhydropodorhizol, not converted into any detectable product. Deoxypodophyllotoxin, in contrast, was converted into podophyllotoxin, yielding significantly higher concentration than measured in whole plants.
    Journal of Health Science, 2011, 57 (57) :184-7.
    Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora[Reference: WebLink]
    Immunoglobulin E (IgE) plays an important role in allergic diseases.
    METHODS AND RESULTS:
    In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as Dimethylmatairesinol. Authentic Dimethylmatairesinol exhibited similar ac-tivity.
    CONCLUSIONS:
    Thus, the extract of C. camphora and its com-ponents including Dimethylmatairesinol have poten-tial as an anti-allergic agent.
    Phytochemistry , 2000 , 55 (3) :227-32.
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    The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated.
    METHODS AND RESULTS:
    Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and Dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells.
    CONCLUSIONS:
    Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis.
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