Dimethylmatairesinol

Planta Med. 2003 Aug;69(8):733-8.

A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.[Pubmed: 14531024]

METHODS AND RESULTS:
In the roots of Anthriscus sylvestris 12 different lignans were detected. Arctigenin, Dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in A. sylvestris. In the cell suspension cultures, which were initiated for this study, trace amounts of deoxypodophyllotoxin could be detected. With these cell suspension cultures we carried out feeding experiments using deoxypodophyllotoxin, yatein and, anhydropodorhizol.
CONCLUSIONS:
Yatein had a toxic effect on the cell cultures and was, like anhydropodorhizol, not converted into any detectable product. Deoxypodophyllotoxin, in contrast, was converted into podophyllotoxin, yielding significantly higher concentration than measured in whole plants.

Journal of Health Science, 2011, 57 (57) :184-7.

Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora[Reference: WebLink]

Immunoglobulin E (IgE) plays an important role in allergic diseases.
METHODS AND RESULTS:
In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as Dimethylmatairesinol. Authentic Dimethylmatairesinol exhibited similar ac-tivity.
CONCLUSIONS:
Thus, the extract of C. camphora and its com-ponents including Dimethylmatairesinol have poten-tial as an anti-allergic agent.

Phytochemistry , 2000 , 55 (3) :227-32.

Cytotoxicity of extractives from Taiwania cryptomerioides heartwood.[Reference: WebLink]

The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated.
METHODS AND RESULTS:
Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and Dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells.
CONCLUSIONS:
Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis.

Spectrochim Acta A Mol Biomol Spectrosc. 2006 Jan;63(1):234-9.

Detailed 1H and 13C NMR structural assignment of three biologically active lignan lactones.[Pubmed: 16344252]

METHODS AND RESULTS:
In this paper we present a complete 1H and 13C NMR spectral analysis of three lignan lactones (methylpluviatolide, Dimethylmatairesinol and hinokinin) by the use of techniques such as COSY, HMQC, HMBC and J-resolved. Complete assignment and all homonuclear hydrogen coupling constant measurements were performed, providing enough data also to the confirmation of the relative stereochemistry.