Sulochrin

Sulochrin
Product Name Sulochrin
CAS No.: 519-57-3
Catalog No.: CFN96651
Molecular Formula: C17H16O7
Molecular Weight: 332.30 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: HCV | Antifection
Source: The culture broth of an Aspergillus species.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotoxicity up to 50 uM. Sulochrin has an inhibitory activity to eosinophil degranulation.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Food Biochem.2019, 43(9):e12970
  • Plant Physiol Biochem.2019, 144:355-364
  • Nutrients.2021, 13(1):254.
  • Journal of Mushroom2023, 21(4):215-221.
  • Food Chem.2023, 424:136383.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Molecules.2021, 26(3):695.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • J Inflamm Res.2022, 15:5347-5359.
  • Korean J. Medicinal Crop Sci.2023, 31(6):388-395.
  • 2,2',3'-Trihydroxy-4,6-dimethoxybenzophenone

    Catalog No: CFN98091
    CAS No: 219861-73-1
    Price: Inquiry(manager@chemfaces.com)
    2,3',4,6-Tetrahydroxybenzophenone

    Catalog No: CFN98302
    CAS No: 26271-33-0
    Price: Inquiry(manager@chemfaces.com)
    Cotoin

    Catalog No: CFN98729
    CAS No: 479-21-0
    Price: $338/10mg
    Cearoin

    Catalog No: CFN89497
    CAS No: 52811-37-7
    Price: Inquiry(manager@chemfaces.com)
    2,6,4'-Trihydroxy-4-methoxybenzophenone

    Catalog No: CFN89307
    CAS No: 55051-85-9
    Price: $318/10mg
    Maclurin

    Catalog No: CFN98836
    CAS No: 519-34-6
    Price: Inquiry(manager@chemfaces.com)
    Iriflophenone

    Catalog No: CFN98864
    CAS No: 52591-10-3
    Price: Inquiry(manager@chemfaces.com)
    Dimethylmatairesinol

    Catalog No: CFN97524
    CAS No: 943989-68-2
    Price: Inquiry(manager@chemfaces.com)
    Iriflophenone 3-C-beta-D-glucopyranoside

    Catalog No: CFN99063
    CAS No: 104669-02-5
    Price: $288/5 mg
    Sulochrin

    Catalog No: CFN96651
    CAS No: 519-57-3
    Price: Inquiry(manager@chemfaces.com)
    Biochem Biophys Res Commun. 2013 Nov 1;440(4):515-20.
    Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives.[Pubmed: 24099774 ]
    Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. Although various classes of anti-HCV agents have been under clinical development, most of these agents target RNA replication in the HCV life cycle.
    METHODS AND RESULTS:
    To achieve a more effective multidrug treatment, the development of new, less expensive anti-HCV agents that target a different step in the HCV life cycle is needed. We prepared an in-house natural product library consisting of compounds derived from fungal strains isolated from seaweeds, mosses, and other plants. A cell-based functional screening of the library identified Sulochrin as a compound that decreased HCV infectivity in a multi-round HCV infection assay. Sulochrin inhibited HCV infection in a dose-dependent manner without any apparent cytotoxicity up to 50 μM. HCV pseudoparticle and trans-complemented particle assays suggested that this compound inhibited the entry step in the HCV life cycle.
    CONCLUSIONS:
    Sulochrin showed anti-HCV activities to multiple HCV genotypes 1a, 1b, and 2a. Co-treatment of Sulochrin with interferon or a protease inhibitor telaprevir synergistically augmented their anti-HCV effects.
    Chem Pharm Bull (Tokyo). 1983 Dec;31(12):4543-8.
    Studies on metabolites produced by Aspergillus terreus var. aureus. I. Chemical structures and antimicrobial activities of metabolites isolated from culture broth[Reference: WebLink]
    A fungus which was identified as Aspergillus terreus var. aureus showed antifungal and antibacterial activities.
    METHODS AND RESULTS:
    Through the investigation of its metabolites, six compounds (1-6) were isolated; emodin (1), dihydrogeodin (2), questin (3), Sulochrin (5), the new metabolite 2-(3-chloro-4-methyl-γ-resorcyloyl)-5-hydroxy-m-anisic acid methyl ester (4), which is a monochloro derivative of Sulochrin (5), and compound (6), the chemical structure of which has not yet been clarified.
    CONCLUSIONS:
    Dihydrogeodin (2), Sulochrin (5), 4 and 6 showed antifungal and antibacterial activities, and 6 has especially strong antifungal activity towards Trichophyton mentagrophytes.
    Bioorg Med Chem Lett. 1999 Jul 19;9(14):1945-8.
    Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.[Pubmed: 10450959]
    Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation.
    METHODS AND RESULTS:
    A series of Sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.
    Epimedin B1

    Catalog No: CFN95017
    CAS No: 133137-58-3
    Price: $268/5mg
    2'-Rhamnoechinacoside

    Catalog No: CFN95035
    CAS No: 1422390-59-7
    Price: $368/10mg
    Tuberosin

    Catalog No: CFN95107
    CAS No: 41347-45-9
    Price: $218/5mg
    6'-Feruloylnodakenin

    Catalog No: CFN95202
    CAS No: 131623-14-8
    Price: $318/10mg
    Biatractylolide

    Catalog No: CFN95205
    CAS No: 182426-37-5
    Price: $268/10mg
    New compound 9

    Catalog No: CFN95342
    CAS No: N/A
    Price: $413/5mg
    Cannabisin M

    Catalog No: CFN95436
    CAS No: 1831134-13-4
    Price: $318/5mg
    Barbaloin-related compound A

    Catalog No: CFN95453
    CAS No: 473225-21-7
    Price: $318/5mg
    Quercetin 3,5-O-diglucoside

    Catalog No: CFN95486
    CAS No: 206257-35-4
    Price: $368/10mg
    Herbacetin 3-sophoroside-8-glucoside

    Catalog No: CFN95529
    CAS No: 77298-68-1
    Price: $318/5mg