Dehydrocorydaline nitrate | CAS:13005-09-9

Dehydrocorydaline has anti-inflammatory activity, it has antinociceptive effects in mouse models of inflammatory pain, the effects involve the opioid receptor and inflammatory cytokines. Dehydrocorydaline can inhibit elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages.Dehydrocorydaline not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially attributed to dehydrocorydaline.

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Fitoterapia.2021, 153:104995.

Srinakharinwirot University2023, 2669.

Antioxidants.2022, 11(3):491.

J Liq Chromatogr R T2018, 41(12):761-769

STAR Protoc.2024, 5(2):102990.

Phytochem Anal.2021, 32(6):970-981.

Pak J Pharm Sci.2019, 32(6):2879-2885

Univerzita Karlova2022, 228192.

Asian Pac J Tropical Bio.2020, 10(6):239-247

Hum. Ecol. Res.2025, 63(2):165-174

Int. Immunopharmacol., 2011, 11(9):1362-7.

Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages.[Pubmed: 21575743 ]

Activated macrophages play a critical role in the pathogenesis of numerous diseases by producing pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6. While the mechanisms of bacterial component recognition and signal transduction have been well investigated, viability regulation in activated macrophages remains unclear.
METHODS AND RESULTS:
We screened herbal ingredients to find an agent that reduces the viability of lipopolysaccharide (LPS)-stimulated macrophages and observed that dehydrocorydaline, a component of Corydalis yanhusuo, reduced the viability of macrophage-derived RAW264.7 cells and primary macrophages in the presence of LPS. Dehydrocorydaline inhibited the elevation of mitochondrial membrane potential and induced ATP depletion in LPS-stimulated macrophages but neither affected basal mitochondrial membrane potential nor ATP content in non-stimulated macrophages. Dehydrocorydaline also prevented increased concentrations of IL-1β and IL-6 in culture media of LPS-stimulated macrophages.
CONCLUSIONS:
Mode of dehydrocorydaline action indicates that elevated mitochondrial membrane potential may be a novel target to specifically reduce viability and suppress cytokine production in LPS-stimulated macrophages.

Product Name	Dehydrocorydaline nitrate
CAS No.:	13005-09-9
Catalog No.:	CFN90604
Molecular Formula:	C₂₂H₂₄NO₄.NO₃
Molecular Weight:	428.44 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Targets:	IL Receptor
Source:	The tubers of Corydalis ambigua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: