11beta,13-Dihydrolactucin

11beta,13-Dihydrolactucin
Product Name 11beta,13-Dihydrolactucin
CAS No.: 83117-63-9
Catalog No.: CFN95433
Molecular Formula: C15H18O5
Molecular Weight: 278.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Picris hieracioides L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
11beta,13-Dihydrolactucin has analgesic effect and anti-inflammatory potential .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Antimicrob Agents Chemother.2024, e0031424.
  • Biomedicines.2022, 10(3):583.
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Journal of Ginseng Research2023, 12.004.
  • Processes2023, 11(2), 385
  • Pharmaceutics.2023, 15(9):2355.
  • Phytother Res.2019, 33(7):1784-1793
  • Biomed Pharmacother.2019, 116:108987
  • J Ethnopharmacol.2019, 235:406-414
  • Am J Chin Med.2015, 30:1-22
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    Cichorium intybus L. has recently gained major attention due to large quantities of health-promoting compounds in its roots, such as inulin and sesquiterpene lactones (SLs). Chicory is the main dietary source of SLs, which have underexplored bioactive potential. In this study, we assessed the capacity of SLs to permeate the intestinal barrier to become physiologically available, using in silico predictions and in vitro studies with the well-established cell model of the human intestinal mucosa (differentiated Caco-2 cells). The potential of SLs to modulate inflammatory responses through modulation of the nuclear factor of activated T-cells (NFAT) pathway was also evaluated, using a yeast reporter system. Lactucopicrin was revealed as the most permeable chicory SL in the intestinal barrier model, but it had low anti-inflammatory potential. The SL with the highest anti-inflammatory potential was 11β,13-dihydrolactucin, which inhibited up to 54% of Calcineurin-responsive zinc finger (Crz1) activation, concomitantly with the impairment of the nuclear accumulation of Crz1, the yeast orthologue of human NFAT.
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