Daphnenone

Daphnenone
Product Name Daphnenone
CAS No.: 936006-13-2
Catalog No.: CFN92257
Molecular Formula: C17H16O2
Molecular Weight: 252.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The roots of Daphne odora
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Daphnenone shows cytotoxic activity against the tumor cells of human melanoma A375-S2 , with the IC(50) value of 29.8 uM.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Prev Nutr Food Sci.2024, 29(4):563-571.
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Front Pharmacol.2021, 12:765521.
  • PLoS One.2018, 13(11):e0208055
  • Biomed Chromatogr.2019, 8:e4774
  • Mol Biol Rep.2024, 51(1):56.
  • APMIS.2019, 127(10):688-695
  • Phytomedicine.2020, 153440.
  • Kasetsart University2022, ethesis.1144.
  • J Nat Med.2018, 72(3):734-744
  • 1,7-Diphenyl-4-hepten-3-one

    Catalog No: CFN92685
    CAS No: 79559-59-4
    Price: $288/5mg
    7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

    Catalog No: CFN95140
    CAS No: 100667-52-5
    Price: $318/5mg
    7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB)

    Catalog No: CFN95139
    CAS No: 79559-60-7
    Price: $268/20mg
    Alnustone

    Catalog No: CFN90620
    CAS No: 33457-62-4
    Price: $50/20mg
    1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one

    Catalog No: CFN95171
    CAS No: 87095-77-0
    Price: $318/10mg
    (R)-5-Hydroxy-1,7-diphenyl-3-heptanone

    Catalog No: CFN92684
    CAS No: 100761-20-4
    Price: $318/10mg
    5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)

    Catalog No: CFN95137
    CAS No: 105955-04-2
    Price: $318/10mg
    (3S,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol

    Catalog No: CFN95195
    CAS No: 87095-75-8
    Price: $318/5mg
    (3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol

    Catalog No: CFN95227
    CAS No: 232261-31-3
    Price: $318/5mg
    5-Hydroxy-1,7-diphenyl-6-hepten-3-one

    Catalog No: CFN97433
    CAS No: 87095-74-7
    Price: $100/20mg
    J Asian Nat Prod Res. 2012;14(11):1020-6.
    Two new compounds with cytotoxic activity on the human melanoma A375-S2 cells from Daphne giraldii callus cells.[Pubmed: 23106433 ]

    METHODS AND RESULTS:
    Four compounds were isolated from Daphne giraldii callus cells, and their structures were characterized as Daphnenone (1), daphnolon (2), R-( - )-1-(4'-hydroxyphenyl)-3-hydroxy-5-phenyl-1,5-pentandione (3), and S-(+)-daphneolone-4'-O-β-d-glucoside (4) on the basis of MS, NMR spectrographic analysis, and chemical methods. All of the four compounds possessed C6-C5-C6 carbon skeleton, and among them, 3 and 4 were two new compounds.
    CONCLUSIONS:
    In activity screening test, compounds 1, 2, 3, and 4 showed different degrees of cytotoxic activity against the tumor cells of human melanoma A375-S2 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide method, with IC(50) values of 29.8, 51.0, 41.0, and 150.0 μM, respectively. Furthermore, we found the important target which could explain the cytotoxic mechanism of the four compounds by using autodock 4.0, a structure-guided discovery approach, and the important residues CYS532, GLY534, and SER535 of B-Raf kinase have been discovered.
    Nat Prod Res. 2006 Dec;20(14):1290-4.
    Two new chemical constituents from Daphne odora Thunb. var. marginata.[Pubmed: 17393653 ]

    METHODS AND RESULTS:
    Two new phenolic constituents, Daphnenone (1) and daphneone (2), were isolated from the stem bark of Daphne odora Thunb. var. marginata. Their structures were established on the basis of spectroscopic analysis. Compounds 1 and 2 were tested for cytotoxic activity by MTT assays on five human tumour cell lines, K562, A549, MCF-7, LOVO and HepG2.
    CONCLUSIONS:
    Compound 1 showed obvious cytotoxic activity against all the five cell lines.
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Arjungenin

    Catalog No: CFN95039
    CAS No: 58880-25-4
    Price: $318/20mg
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    Cassiaside C

    Catalog No: CFN95120
    CAS No: 119170-52-4
    Price: $318/10mg
    Polygalin J

    Catalog No: CFN95175
    CAS No: N/A
    Price: $318/5mg
    Yuanhunine

    Catalog No: CFN95179
    CAS No: 104387-15-7
    Price: $368/5mg
    9-Octadecenedioic acid

    Catalog No: CFN95301
    CAS No: 4494-16-0
    Price: $100/20mg
    Quercetin 3,5-O-diglucoside

    Catalog No: CFN95486
    CAS No: 206257-35-4
    Price: $368/10mg
    New compound 20

    Catalog No: CFN95545
    CAS No: N/A
    Price: $413/5mg
    Ephedrannin D1

    Catalog No: CFN95547
    CAS No: 1592431-55-4
    Price: $318/5mg