Product Name Daphnenone
CAS No.: 936006-13-2
Catalog No.: CFN92257
Molecular Formula: C17H16O2
Molecular Weight: 252.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The roots of Daphne odora
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Daphnenone shows cytotoxic activity against the tumor cells of human melanoma A375-S2 , with the IC(50) value of 29.8 uM.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Food Chem.2021, 360:130063.
  • Planta Med.2018, 84(6-07):465-474
  • Kasetsart University2022, ethesis.1144.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Molecules.2020, 25(21):5087.
  • Toxicol Rep.2021, 8:1131-1142.
  • Appl. Sci.2020, 10(16),5482.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Molecules.2021, 26(2):E255.
  • 3-Hydroxy-1,5-diphenyl-1-pentanone

    Catalog No: CFN92628
    CAS No: 60669-64-9
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN92258
    CAS No: 54835-64-2
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN92685
    CAS No: 79559-59-4
    Price: $288/5mg

    Catalog No: CFN95140
    CAS No: 100667-52-5
    Price: $318/5mg
    7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB)

    Catalog No: CFN95139
    CAS No: 79559-60-7
    Price: $268/20mg

    Catalog No: CFN90620
    CAS No: 33457-62-4
    Price: $50/20mg

    Catalog No: CFN95171
    CAS No: 87095-77-0
    Price: $318/10mg

    Catalog No: CFN92684
    CAS No: 100761-20-4
    Price: Inquiry(manager@chemfaces.com)
    5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)

    Catalog No: CFN95137
    CAS No: 105955-04-2
    Price: $268/20mg

    Catalog No: CFN95195
    CAS No: 87095-75-8
    Price: $318/5mg
    J Asian Nat Prod Res. 2012;14(11):1020-6.
    Two new compounds with cytotoxic activity on the human melanoma A375-S2 cells from Daphne giraldii callus cells.[Pubmed: 23106433 ]

    Four compounds were isolated from Daphne giraldii callus cells, and their structures were characterized as Daphnenone (1), daphnolon (2), R-( - )-1-(4'-hydroxyphenyl)-3-hydroxy-5-phenyl-1,5-pentandione (3), and S-(+)-daphneolone-4'-O-β-d-glucoside (4) on the basis of MS, NMR spectrographic analysis, and chemical methods. All of the four compounds possessed C6-C5-C6 carbon skeleton, and among them, 3 and 4 were two new compounds.
    In activity screening test, compounds 1, 2, 3, and 4 showed different degrees of cytotoxic activity against the tumor cells of human melanoma A375-S2 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide method, with IC(50) values of 29.8, 51.0, 41.0, and 150.0 μM, respectively. Furthermore, we found the important target which could explain the cytotoxic mechanism of the four compounds by using autodock 4.0, a structure-guided discovery approach, and the important residues CYS532, GLY534, and SER535 of B-Raf kinase have been discovered.
    Nat Prod Res. 2006 Dec;20(14):1290-4.
    Two new chemical constituents from Daphne odora Thunb. var. marginata.[Pubmed: 17393653 ]

    Two new phenolic constituents, Daphnenone (1) and daphneone (2), were isolated from the stem bark of Daphne odora Thunb. var. marginata. Their structures were established on the basis of spectroscopic analysis. Compounds 1 and 2 were tested for cytotoxic activity by MTT assays on five human tumour cell lines, K562, A549, MCF-7, LOVO and HepG2.
    Compound 1 showed obvious cytotoxic activity against all the five cell lines.
    Dactylorhin A

    Catalog No: CFN95032
    CAS No: 256459-34-4
    Price: $238/20mg
    8-Hydroxypinoresinol diglucoside

    Catalog No: CFN95083
    CAS No: 112747-99-6
    Price: $318/5mg

    Catalog No: CFN95123
    CAS No: 1221686-60-7
    Price: $398/5mg
    Safflospermidine A

    Catalog No: CFN95255
    CAS No: N/A
    Price: $413/5mg
    Fortunellin-6''-beta-D-glucopyranoside (Acacetin-7-O-[2''-O-rhamnosyl-6''-O-glucosyl]-glucoside)

    Catalog No: CFN95315
    CAS No: 1218774-64-1
    Price: $318/5mg
    Crepidiaside B

    Catalog No: CFN95432
    CAS No: 101921-35-1
    Price: $318/10mg
    Malabaricone C

    Catalog No: CFN95475
    CAS No: 63335-25-1
    Price: $318/10mg
    New compound 18

    Catalog No: CFN95527
    CAS No: N/A
    Price: $413/5mg
    Methyl ganoderate F

    Catalog No: CFN95584
    CAS No: 98665-08-8
    Price: $368/5mg
    11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid

    Catalog No: CFN95592
    CAS No: 1245703-70-1
    Price: $413/5mg