3-Hydroxy-1,5-diphenyl-1-pentanone

J Asian Nat Prod Res. 2001;3(4):335-40.

A new bicoumarin from Stellera chamaejasme L.[Pubmed: 11783587]

METHODS AND RESULTS:
Thirteen compounds were isolated from roots of Stellera chamaejasme L. (Thymelaeaceae). They are 3-sitosterol (2), simplexin (3), pimelea factor P2 (4), daucosterol (5), (+)-3-Hydroxy-1,5-diphenyl-1-pentanone (6), 4-ethoxy-benzoic acid (7), 2,4,6-Trimethoxy-benzoic acid (8), (+)-afzelechin (9), fumaric acid (10), N,N-dimethyl-L-aspartic acid (11), umbelliferone (12), daphniretin (13) and a novel bicoumarin named bicoumastechamin (1). Among the known compounds, 7, 8, 9, 10 and 11 were first isolated from this plant, and (+)-3-Hydroxy-1,5-diphenyl-1-pentanone was first isolated from the natural resources. Their structures have been elucidated on the basis of spectral data.
CONCLUSIONS:
In vitro bioassays showed that 4 inhibited cancer cell growth, 13 exhibited immunomodulatory activity, and 6 exhibited both immunomodulatory and anti-tumor activity.

Molecules. 2013 Mar 5;18(3):2988-96.

Oleodaphnoic acid and coriaceol, two new natural products from the stem bark of Wikstroemia coriacea.[Pubmed: 23462531]

METHODS AND RESULTS:
Fractionation of the chloroform extract of Wikstroemia coriacea led to the isolation of two new compounds, oleodaphnoic acid (1), a guaiane-type sesquiterpenoid, and coriaceol (2), an 1,5-diphenyl-1-pentanone analogue, together with nine known compounds. The structures of 1 and 2 were elucidated by extensive spectroscopic data analysis.
CONCLUSIONS:
The known compounds were oleodaphnal (3), indicanone (4), (5R,8R,8aR)-3,8-dimethyl-4,5,6,7,8,8a-hexahydro-5-(1-methylethenyl)-2(1H)-azulenone, (5), 1,5 diphenyl-1-pentanone (6), (+)-3-Hydroxy-1,5-diphenyl-1-pentanone (7), umbelliferone (8), daphnoretin (9), β-sitostenone (10) and (-)-hinokinin (11).