Corypalmine
Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Folia Microbiol (Praha). 2002;47(3):287-90.
Efficacy of alkaloid (-)-corypalmine against spore germination of some fungi.[Pubmed:
12094740]
METHODS AND RESULTS:
Inhibition activity of the alkaloid (-)-Corypalmine on spore germination of plant pathogenic and saprophytic fungi (Alternaria solani, A brassicicola, A. brassicae, A. melongenae, Curvularia pallescens, C. lunata, C. maculans, Curvularisa sp., Colletotrichum sp., Helminthosporium speciferum, H. frumentacei, H. pennisetti, Heterosporium sp., Penicillum sp., Ustilago cynodontis) was determined.
CONCLUSIONS:
Spore germination of all the tested fungi was inhibited, Heterosporium sp. and Ustilago cynodontis being the most sensitive (complete inhibition of spore germination was observed at the very low concentration of 200 ppm). Curvularia palliscens, C. maculans and Curvularia sp. were less sensitive; complete inhibition of spore germination occurred at 400 ppm.
Fitoterapia. 2015 Jun;103:192-6.
Isoquinoline alkaloids as prolyl oligopeptidase inhibitors.[Pubmed:
25863351]
Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications.
METHODS AND RESULTS:
Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase.
CONCLUSIONS:
Promising results have been showed by alkaloids californidine (IC50=55.6±3.5 μM), dihydrosanquinarine (IC50=99.1±7.6 μM), Corypalmine (IC50=128.0±10.5 μM) and N-methyllaurotetanine (IC50=135.0±11.7 μM).
Nat Prod Res. 2009;23(3):250-5.
New alkaloids from Corydalis species.[Pubmed:
19235025]
METHODS AND RESULTS:
A new alkaloid, chaerophylline (1), together with known alkaloids (-)-Corypalmine, berberine chloride, (-)-isoCorypalmine, (-)-corydalmine and (+)-bicuculline have been isolated from the crude base fraction of Corydalis chaerophylla. The crude base fractions of Corydalis longipes gave a new alkaloid, longicine (4), together with known alkaloids (+/-)-alpha-hydrastine, (+/-)-beta-hydrastine, N-methylhydrasteine hydroxylactam, 1-methoxyberberine chloride and berberinium hydroxide.
CONCLUSIONS:
These alkaloids are reported for the first time from the above species and their structures were established by chemical and spectroscopic evidence.
