Bruceantinoside A
Bruceantinoside A has antileukemic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Natural Product Communications2023, 18(9).
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Chem Biol Interact.2024, 395:110999.
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Phytother Res. 2011 Dec;25(12):1796-800.
Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.[Pubmed:
21480411]
Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines.
METHODS AND RESULTS:
A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, yadanzioside A, yadanzioside G, javanicoside C and Bruceantinoside A. Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 μm and 0.10 μm on PANC-1 and SW1990 cell lines, respectively.
CONCLUSIONS:
This is the first report on the antipancreatic adenocarcinoma activity of brusatol.
J Nat Prod. 1981 Jul-Aug;44(4):470-4.
Antitumor agents. 39. Bruceantinoside-A and -B, novel antileukemic quassinoid glucosides from Brucea antidysenterica.[Reference:
WebLink]
METHODS AND RESULTS:
The new antileukemic quassinoid glucosides Bruceantinoside A (1) and bruceantinoside B (2) were isolated from Brucea antidysenterica.
CONCLUSIONS:
The structure of 1 and 2 has been established from chemical transformation, correlations and spectral analyses, especially the 13C-nmr spectral data.
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