Dehydrobruceantin

Dehydrobruceantin
Product Name Dehydrobruceantin
CAS No.: 53662-98-9
Catalog No.: CFN89337
Molecular Formula: C28H34O11
Molecular Weight: 546.56 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: Antifection
Source: The seeds of Brucea javanica (L.) Merr.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Dehydrobruceantin has anti-tuberculosis activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9.
    Anti-tuberculosis activity of quassinoids.[Pubmed: 9332005]

    METHODS AND RESULTS:
    In vitro evaluation of anti-tuberculosis activity was conducted for fifty-six quassinoids isolated in our laboratory from Simaroubaceous plants, Ailanthus altissima (= Aa, 10 compounds), Brucea antidysenterica (= Ba, 16 compounds), Picrasma ailanthoides (= Pa, 14 compounds), and Brucea javanica (= Bj, 16 compounds).
    CONCLUSIONS:
    Of the compounds tested, shinjulactone K (1), ailanthone (2), shinjudilactone (3), and Dehydrobruceantin (4) were the most potent. Although the activities were very low (0-19%), the resulting data provided a picture of structure-activity relationships.
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    METHODS AND RESULTS:
    The isolation and structural elucidation of the new potent antileukemic principles, bruceantin (1) and bruceantinol (3), and the new companion quassinoids, bruceantarin (2), Dehydrobruceantin (8), dehydrobruceantarin (9), dehydrobruceine B (10), dehydrobruceantol (11), and isobruceine B (12), are reported. Bruceantin (1), bruceantinol (3), and bruceantarin (2) were shown by hydrolysis to be trans-3,4-dimethyl-2-pentenoate, trans-4-hydroxy-3,4-dimethyl-2-pentenoate, and benzoate esters, respectively, of bruceolide (5).
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