Yadanzioside A

Phytother Res. 2011 Dec;25(12):1796-800.

Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.[Pubmed: 21480411 ]

Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines.
METHODS AND RESULTS:
A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, Yadanzioside A, yadanzioside G, javanicoside C and bruceantinoside A.
CONCLUSIONS:
Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 μm and 0.10 μm on PANC-1 and SW1990 cell lines, respectively. This is the first report on the antipancreatic adenocarcinoma activity of brusatol.

Chemical & pharmaceutical bulletin, 1984, 32(11), 4702-5.

New quassinoid glycosides, yadanziosides A-H, from Brucea javanica.[Reference: WebLink]

Eight new antileukemic quassinoid glycosides, Yadanzioside A, yadanzioside B, yadanzioside C, yadanzioside D, yadanzioside E, Yadanzioside F, yadanzioside G, and yadanzioside H(1-8) were isolated from seeds of Brucea javanica and their structures were determined by chemical transformation and spectral analysis.

Bull. Chem. Soc. Jpn.,1985, 58(9), 2680-6.

Structures of new quassinoid glycosides, yadanziosides A,B,C,D,E,G,H, and new quassinoids, dehydrobrusatol and dehydrobruceantinol from Brucea javanica (L.) Merr.[Reference: WebLink]

METHODS AND RESULTS:
Quassinoid glycosides, Yadanzioside A, yadanzioside B, yadanzioside C, yadanzioside D, yadanzioside E, yadanzioside G, and yadanzioside H, and two quassinoids, dehydrobrusatol and dehydrobruceantinol were isolated from seeds of Brucea javanica, and their structures were determined.
CONCLUSIONS:
These glycosides showed bitter taste and were demonstrated to have antileukemic activity.