Astragaloside III

Astragaloside III
Product Name Astragaloside III
CAS No.: 84687-42-3
Catalog No.: CFN99174
Molecular Formula: C41H68O14
Molecular Weight: 784.97 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The roots of Astragalus membranaceus (Fisch.) Bunge
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $288/10mg
Astragaloside III has anti-gastric ulcer effects, and exhibits strong growth-promoting effects in cultured GES-1 cells. Astragaloside III can effectively reduce cancer cell survival in vitro and inhibit the tumor growth in vivo, the potential mechanism is the induction of cell apoptosis signaling pathways, suggests that it provides a new therapeutic tool to treat breast cancer.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Fitoterapia. 2010 Jul;81(5):447-51.
    Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets.[Pubmed: 20060881]
    For the first time three different natural compounds, isolated from hairy roots of Astragalus membranaceus, cultivated in airlift bioreactor were tested for their cytotoxic potential and apoptosis induction in a panel of human tumor cell lines.
    METHODS AND RESULTS:
    Root cultures, cultivated in bioreactor gave 18.5 g l(-1) dry wt roots with the highest astragaloside production in vitro up to now - 1.64% (astragaloside I), 1.12% (astragaloside II) and 1.08% (Astragaloside III).
    CONCLUSIONS:
    In this manner the production in airlift bioreactor can be used as means of reliable supply of cycloartane saponins to extend the research to human clinical studies.
    Afr. J. Tradit. Complem., 2015, 12(3):183-6.
    Astragaloside III from Astragalus membranaceus antagonizes breast cancer growth[Reference: WebLink]
    Astragaloside III has been used to treat different cancers; however their effect on breast cancer remains unknown.
    METHODS AND RESULTS:
    The present study examined the effects of Astragaloside III from Astragalus membranaceus on breast cancer cell lines in vitro as well as xenograft in vivo. The results showed that the Astragaloside III could effectively reduce cancer cell survival in vitro and inhibit the tumor growth in vivo. The potential mechanism is the induction of cell apoptosis signaling pathways.
    CONCLUSIONS:
    We believe that Astragaloside III provides a new therapeutic tool to treat breast cancer.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1;960:43-51.
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    CONCLUSIONS:
    The results of this study can be used to evaluate the quality of Radix Astragali and to provide a theoretical foundation for its further study.
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