Anwulignan
Anwuligan has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. (+)-Anwulignan has inhibitory effects on platelets aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Shanghai Medica, 2005, 32(4):467-70.
Effects of heteroclitin D, schisanhenol and ( + )-anwulignan on platelet aggregation.[Reference:
WebLink]
To investigate the effects of three lignans: heteroclitin D (HD), schisanhenol (SAL) and ( + )-Anwulignan(AN) with different skeletons from Schisandraceae medicinal plants on platelet aggregation.
METHODS AND RESULTS:
At concentrations 0.05-25 mg/L of the three lignans, rabbit platelet aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) were studied by Born's turbidimetry, the maximum time of platelet aggregation and platelet aggregation at 1,3,5 min were also observed. 1 HD and SAL inhibited the ADP- and PAF-induced platelet aggregation in a concentration-dependant manner. The inhibitory effect of AN was weak. 2 ADP-induced platelet aggregation at 1, 3,5 min were inhibited by HD and SAL in a similar manner. At 5 mg/L,AN inhibited platelet aggregation at 3 and 5 min significantly;The PAF-induced platelet aggregation at 1,3,5 min, the inhibition of HD at 1,3 min and of SAL at 3,5 min were more potent. 3 HD, SAL and AN had no effects on maximum time of ADP- and PAF-induced platelet aggregation.
CONCLUSIONS:
HD,SAL and AN have inhibitory effects on platelets aggregation induced by ADP and PAF in vitro. The inhibitory effect of HD is the most potent and could be one of the important active components from Kadsura medicinal plants.
Chin Med . 2011 Mar 4;6:10.
Effects of a multi-herbal extract on type 2 diabetes[Pubmed:
21375727]
Abstract
Background: An aqueous extract of multi-hypoglycemic herbs of Panax ginseng C.A.Meyer, Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus and Evodia officinalis was investigated for its anti-diabetic effects in cell and animal models.
Methods: Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in db/db mice (a genetic animal model for type 2 diabetes).
Results: While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The db/db mice treated with the extract showed reduced fasting blood glucose and HbA1c levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.
Conclusion: The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.
Se Pu. 2009 May;27(3):313-7.
Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography.[Pubmed:
19803136]
METHODS AND RESULTS:
The systems of mobile phase for the determination of gamma-schisandrin in Schisandra chinensis and its preparations were developed by high performance liquid chromatography (HPLC). The separation was performed on a Shim-pack VP-ODS column (250 mm x 4.6 mm, 5 microm) at 30 degrees C, the detection wavelength was set at 285 nm and the flow rate was 1.0 mL/min. Retention times and separation were investigated in mixed solution of three reference substances (gamma-schisandrin, Anwulignan, and deoxyschizandrin) and methanol extract of Schisandra chinensis by different systems and proportions of mobile phases to select optimal conditions for the determination of gamma-schisandrin. The results showed that the complete separation of gamma-schisandrin and Anwulignan was difficult in the systems of methanol-water and methanol-acetic acid-water. The separation of gamma-schisandrin, Anwulignan and deoxyschizandrin can be completed in the systems of acetonitrile-methanol-water and acetonitrile-acetic acid-water when their proportions were suitable. The mobile phase of acetonitrile-methanol-water (17:58:25, v/v/v) was selected for the determination of deoxyschizandrin, gamma-schisandrin and Anwulignan in Schisandra chinensis and Hugan tablets.
CONCLUSIONS:
The determination results of the three substances were satisfactory with the relative standard deviations (n = 4) ranged from 0.95% to 5.8%, and the average recoveries ranged from 94.50% to 105.6%. The efficiency of separation and the results of determination were satisfactory for the real samples.
