Alismol
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. Alismol has inhibitory effect to MMP3 expression and nitric oxide produced in microglial cells. It holds great promise for use in chemopreventive and chemotherapeutic strategies.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Jpn J Pharmacol. 1988 Apr;46(4):331-5.
Effect of alismol on adrenergic mechanism in isolated rabbit ear artery.[Pubmed:
3404764 ]
Effects of Alismol, a sesquiterpenoid isolated from the rhyzome of Alisma orientale, on adrenergic mechanisms were examined in the isolated rabbit ear artery.
METHODS AND RESULTS:
Alismol (10(-6) to 10(-4) M) inhibited the contraction of isolated rabbit ear artery by electrical stimulation of the perivascular nerves. The inhibition was concentration-dependent; at a concentration of 10(-4) M, the inhibition was 90% (n = 8). Treatment with 10(-4) M Alismol inhibited the increase in 3H-noradrenaline (3H-NAd) release induced by electrical stimulation by 63 +/- 6%. Alismol at 10(-4) M did not affect the neuronal uptake of 3H-NAd in the artery. Alismol at 10(-4) M slightly inhibited contractions induced by exogenously administered NAd.
CONCLUSIONS:
These results demonstrate that Alismol inhibits the adrenergic neuro-effector mechanisms in rabbit ear artery, and they suggest that Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release.
Life Sci. 1987 Oct 12;41(15):1845-52.
Effects of alismol isolated from Alismatis Rhizoma on calcium-induced contraction in the rabbit thoracic aorta.[Pubmed:
3657386]
METHODS AND RESULTS:
We examined the inhibitory effects of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, on vascular contractions induced by high concentrations of K+ and Ca2+, and on 45Ca2+ retention in normal and in high K+-containing medium. Alismol affected neither the resting tension nor the 45Ca2+ retention in normal medium, but it inhibited sustained contraction and increased 45Ca2+ retention induced by high K+ concentrations. Alismol did not affect norepinephrine-induced contractions in normal medium, nor phasic contractions in Ca2+-free medium.
CONCLUSIONS:
These results suggested that Alismol inhibited mainly Ca2+ influx through a voltage-dependent Ca2+ channel.
Phytother. Res., 1989, 3(2):72-4.
Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat.[Reference:
WebLink]
METHODS AND RESULTS:
The effect of Alismol (Oshima et al., 1983), a sesquiterpenoid isolated from Alismatis Rhizoma which is used as a Chinese crude drug, was studied on rat isolated heart using the working heart perfusion technique. Alismol decreased cardiac output, heart rate and left ventricular pressure, but it increased coronary flow.
CONCLUSIONS:
The drug has been used for the prevention of anginal attacks and our results provide a pharmacological basis for one of the traditional medicinal effects of Alismatis Rhizoma.
Phytother. Res., 1989, 3(2):57-60.
The effect of alismol isolated from Alismatis Rhizoma on experimental hypertensive models in rats.[Reference:
WebLink]
METHODS AND RESULTS:
The antihypertensive action of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of Alismol on the activation of plasma renin, angiotensin-converting enzyme (ACE) and the level of aldosterone were examined in 2-kidney, 1-clip hypertensive model.
CONCLUSIONS:
Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.
Experimental Technology & Management, 2012, 29(10):47-50.
Inhibitory effect of alismol to MMP3 expression and nitric oxide produced in microglial cells.[Reference:
WebLink]
This paper investigates the inhibitory effect and mechanism of Alismol on neuroinflammation in the activated BV2 microglial cells which are stimulated by lipopolysaccharides(LPS).
METHODS AND RESULTS:
NO was measured by using Griess reagent.RT-PCR and Western blot are used to analyse ERK,JNK,Akt,and MMP3.Alismol can significantly inhibit LPS-induced NO production and the MMP3 expression.The mechanism is involved to its inhibition of PI3K/Akt pathway.
Evid Based Complement Alternat Med. 2013;2013:257108.
In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria.[Pubmed:
23762112]
METHODS AND RESULTS:
Bioassay-guided isolation of the active hexane fractions of Curcuma zedoaria led to the identification of five pure compounds, namely, curzerenone (1), neocurdione (2), curdione (3), Alismol (4), and zederone (5) and a mixture of sterols, namely, campesterol (6), stigmasterol (7), and β -sitosterol (8). Alismol has never been reported to be present in Curcuma zedoaria. All isolated compounds except (3) were evaluated for their cytotoxic activity against MCF-7, Ca Ski, and HCT-116 cancer cell lines and noncancer human fibroblast cell line (MRC-5) using neutral red cytotoxicity assay. Curzerenone and Alismol significantly inhibited cell proliferation in human cancer cell lines MCF-7, Ca Ski, and HCT-116 in a dose-dependent manner. Cytological observations by an inverted phase contrast microscope and Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with curzerenone and Alismol. Both compounds induce apoptosis through the activation of caspase-3. It can thus be suggested that curzerenone and Alismol are modulated by apoptosis via caspase-3 signalling pathway.
CONCLUSIONS:
The findings of the present study support the use of Curcuma zedoaria rhizomes in traditional medicine for the treatment of cancer-related diseases. Thus, two naturally occurring sesquiterpenoids, curzerenone and Alismol, hold great promise for use in chemopreventive and chemotherapeutic strategies.
